Desmopressin vs alpha‐blocker
Withdrawals due to adverse events
1 finding from 1 review
- no estimate extracted1 study · 31 participantsLow
Findings
What do systematic reviews say?
81 questions · 95 findings · 6 reviews
No studies found 25 · 26.3%GRADE not reported 1 · 1.1%Very low 21 · 22.1%Low 39 · 41.1%Moderate 9 · 9.5%High 0 · 0%
Desmopressin plus alpha‐blocker vs alpha‐blocker
Number of nocturnal voids
1 finding from 1 review
- no estimate extracted3 studies · 341 participantsModerate
Desmopressin plus alpha‐blocker vs alpha‐blocker
Quality of life
1 finding from 1 review
- no estimate extracted3 studies · 341 participantsModerate
Desmopressin plus alpha‐blocker vs alpha‐blocker
Major adverse events
Desmopressin plus alpha‐blocker showed no clear difference in major adverse events compared with alpha‐blocker (low certainty).
1 finding from 1 review
- RR 0.3 [0.01, 7.32]3 studies · 402 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker
Duration of first sleep episode ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Desmopressin plus alpha‐blocker vs alpha‐blocker
Time to first void ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Desmopressin plus alpha‐blocker vs alpha‐blocker
Minor adverse events
It is very uncertain whether desmopressin plus alpha‐blocker changes minor adverse events compared with alpha‐blocker (very low certainty).
1 finding from 1 review
- RR 1.6 [0.15, 16.82]3 studies · 402 participantsVery low
Desmopressin plus alpha‐blocker vs alpha‐blocker
Withdrawals due to adverse events
Desmopressin plus alpha‐blocker showed no clear difference in treatment withdrawal due to adverse event compared with alpha‐blocker (low certainty).
1 finding from 1 review
- RR 2.84 [0.46, 17.66]3 studies · 402 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Number of nocturnal voids
1 finding from 1 review
- no estimate extracted1 study · 405 participantsModerate
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Quality of life ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Major adverse events
1 finding from 1 review
- no estimate extracted1 study · 427 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Duration of first sleep episode ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Time to first void ‐ not reported
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Minor adverse events
Desmopressin plus alpha‐blocker may leads to lower minor adverse events compared with alpha‐blocker plus anticholinergic (low certainty).
1 finding from 1 review
- RR 0.22 [0.05, 0.98]1 study · 427 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Withdrawals due to adverse events
Desmopressin plus alpha‐blocker may leads to lower treatment withdrawal due to adverse event compared with alpha‐blocker plus anticholinergic (low certainty).
1 finding from 1 review
- RR 0.22 [0.05, 0.98]1 study · 427 participantsLow
Intervention not reported
Desmopressin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review
- Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a… 2024 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedLow
Alarm plus other intervention vs other interventions
Mean number of wet nights a week · children with nocturnal enuresis
1 finding from 1 review
- no estimate extracted2 studies · 156 participantsLow
Alarm plus other intervention vs other interventions
Proportion of children achieving 14 consecutive dry nights by the end of treatment · children with nocturnal enuresis
Alarm plus other intervention may leads to higher proportion of children achieving 14 consecutive dry nights by the… compared with other intervention (low certainty).
1 finding from 1 review
- RR 1.32 [1.08, 1.62]5 studies · 359 participantsLow
Tricyclic antidepressants vs Other Drug for
Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis
It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with another drug (very low certainty).
2 findings from 1 review
- Tricyclic and related drugs for nocturnal enuresis in children 2016 · Cochrane Headline outcomes onlyRR 2.39 [1.35, 4.25]1 study · 45 participantsVery low
- Tricyclic and related drugs for nocturnal enuresis in children 2016 · Cochrane Headline outcomes onlyRR 0.88 [0.64, 1.2]4 studies · 222 participantsVery low
Intervention not reported
Number of wet nights per week at the end of treatment ‐ Amitriptyline + desmopressin vs amitriptyline · children with nocturnal enuresis
1 finding from 1 review
- Tricyclic and related drugs for nocturnal enuresis in children 2016 · Cochrane Headline outcomes onlyno estimate extracted1 study · 28 participantsVery low