Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 64 findings · 4 reviews · Kidney and Transplant

No studies found 5 · 7.8%GRADE not reported 0 · 0%Very low 15 · 23.4%Low 40 · 62.5%Moderate 4 · 6.3%High 0 · 0%

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Number with complete remission: complete remission in delayed steroid resistance · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes number with complete remission: complete remission in delayed… compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Complete remission · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes number with complete remission: complete remission in all patients compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: bronchospasm/treatment discontinued · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: bronchospasm/treatment discontinued compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: hypotension · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: hypotension compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse effects of antibiotics (skin rash) · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: skin rash compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: mild dyspnoea · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: mild dyspnoea compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

Cyclosporin plus prednisolone vs prednisolone

Adverse effects: number needing cytotoxic agents · SSNS in children

It is very uncertain whether cyclosporin plus prednisolone changes adverse effects: number needing cytotoxic agents compared with prednisolone alone (very low certainty).

1 finding from 1 review