Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

502 questions · 511 findings · 20 reviews · Headline outcomes only

No studies found 76 · 14.9%GRADE not reported 169 · 33.1%Very low 107 · 20.9%Low 92 · 18%Moderate 46 · 9%High 21 · 4.1%

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Combination silicone foam dressings · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes combination silicone foam dressings compared with saline gauze (very low certainty).

1 finding from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke
2 findings from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke

Pharmacological intervention and non‐invasive brain stimulation… may leads to lower depression: meeting the criteria for depression at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (low certainty).

2 findings from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes depression: < 50% reduction in scale scores at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: death (secondary outcome) compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ central nervous system events (e.g. headache, seizures) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ central nervous system events (e.g. headache,… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ other events ‐ not listed above (e.g.… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Perception of improvement or cure · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in subjective cure or improvement: patient‐reported as defined by the… compared with no treatment, sham treatment or verbal/written instruction (low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Disease‐specific quality of life · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in condition‐specific quality of life: using validated questionnaires,… compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Objective cure or improvement: > 6 to 12 months · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in objective cure or improvement: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (high certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Adherence · men with urinary incontinence following prostate surgery

It is very uncertain whether combinations of conservative treatments changes participant adherence to the intervention: as reported by the… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

QoL · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in general quality of life: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Number of participants experiencing muscle‐related adverse events: e.g. soreness, discomfort, cramps, pain · men with urinary incontinence following prostate surgery

It is very uncertain whether combinations of conservative treatments changes number of participants experiencing muscle‐related adverse events:… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

1 finding from 1 review