Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

522 questions · 532 findings · 23 reviews

No studies found 88 · 16.5%GRADE not reported 174 · 32.7%Very low 111 · 20.9%Low 92 · 17.3%Moderate 46 · 8.6%High 21 · 3.9%

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

2 findings from 1 review

Pharmacological interventions vs placebo

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: < 50% reduction in scale scores at end of treatment… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse effects (central nervous system) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ central nervous system events (e.g. confusion,… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Combination silicone foam dressings · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes combination silicone foam dressings compared with saline gauze (very low certainty).

1 finding from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke
2 findings from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: meeting study criteria for depression at end of · people with depression after stroke

Pharmacological intervention and non‐invasive brain stimulation… may leads to lower depression: meeting the criteria for depression at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (low certainty).

2 findings from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes depression: < 50% reduction in scale scores at end of treatment… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke
1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: death (secondary outcome) compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ central nervous system events (e.g. headache, seizures) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ central nervous system events (e.g. headache,… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Adverse events: all ‐ other events ‐ not listed above (e.g. dysuria, neck pain, eye discomfort) (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological intervention and non‐invasive brain stimulation… changes adverse events: all ‐ other events ‐ not listed above (e.g.… compared with a pharmacological intervention and sham stimulation or usual care… (very low certainty).

1 finding from 1 review

Combination system (Isolite) vs Conventional dental suction (low-volume evacuator / saliva ejector)

Reduction in contamination of aerosols (CFU) after ultrasonic scaling / AGP · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether combination system (Isolite) changes reduction in contamination of aerosols (CFU) after ultrasonic… compared with saliva ejector (low-volume evacuator) (very low certainty).

2 findings from 1 review

Combination system (Isolite) vs Rubber dam + HVE

Reduction in level of contamination in aerosols (CFU) during water spray using high-speed handpiece · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether combination system (Isolite) changes reduction in level of contamination in aerosols (CFU) during water… compared with rubber dam + HVE (very low certainty).

1 finding from 1 review