Findings

What do systematic reviews say?

32 questions · 32 findings · 3 reviews · Vascular

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No studies found 5 · 15.6%GRADE not reported 5 · 15.6%Very low 8 · 25%Low 10 · 31.3%Moderate 4 · 12.5%High 0 · 0%

IM injection vs IA injection

Rate of amputation · people with critical limb ischaemia

IM injection showed no clear difference in amputation rate Assessed during in‐patient stay compared with IA injection (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.8 [0.54, 1.18]
3 studies · 95 participants
Low

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1.13 [0.73, 1.76]
1 study · 41 participants
Low

IM injection vs IA injection

Rest‐pain relief · people with critical limb ischaemia

IM injection showed no clear difference in reduction in rest pain: number of participants with reduction in… compared with IA injection (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1.22 [0.91, 1.64]
1 study · 32 participants
Low

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.93 [0.43, 2]
1 study · 35 participants
Very low

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1.22 [0.86, 1.72]
2 studies · 62 participants
Very low

BM‐MNCs vs mPBSCs

Ulcer healing · people with critical limb ischaemia

BM‐MNCs showed no clear difference in wound/ulcer healing: number of participants with healing ulcers… compared with mPBSCs (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.89 [0.44, 1.83]
1 study · 49 participants
Low

BM‐MNCs vs mPBSCs

Rest‐pain relief · people with critical limb ischaemia

BM‐MNCs showed no clear difference in reduction in rest pain: number of participants with any reduction in… compared with mPBSCs (moderate certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 0.99 [0.93, 1.06]
1 study · 104 participants
Moderate

BM‐MNCs vs mPBSCs

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

BM‐MNCs showed no clear difference in improvement in lower limb perfusion: number of participants with… compared with mPBSCs (low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 1 [0.71, 1.4]
1 study · 104 participants
Low

BM‐MNCs vs mPBSCs

Improvement in lower limb perfusion: TcO₂ reading in mmHg · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Low

BM‐MNCs vs BM‐MSCs

All‐cause mortality during hospital stay · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
GRADE not reported

BM‐MNCs vs BM‐MSCs

Rate of amputation · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
GRADE not reported

BM‐MNCs vs BM‐MSCs

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

BM‐MNCs probably leads to higher wound/ulcer healing: number of participants with healing ulcers compared with BM‐MSCs (moderate certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 2 [1.02, 3.92]
1 study · 22 participants
Moderate