Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 42 findings · 5 reviews · Headline outcomes only

No studies found 7 · 16.7%GRADE not reported 3 · 7.1%Very low 8 · 19%Low 13 · 31%Moderate 9 · 21.4%High 2 · 4.8%

Celecoxib vs placebo

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review

Celecoxib vs placebo

Cardiovascular events (myocardial infarction, stroke) · patients with rheumatoid arthritis
1 finding from 1 review

Celecoxib vs placebo

Incidence of gastroduodenal ulcers ≥ 3 mm · patients with rheumatoid arthritis

Celecoxib showed no clear difference in incidence of gastroduodenal ulcers ≥ 3 mm compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Short‐term serious adverse events · patients with rheumatoid arthritis

Celecoxib showed no clear difference in short‐term serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Total number of withdrawals · patients with rheumatoid arthritis

Celecoxib may leads to lower total withdrawals; compared with placebo (low certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Clinical improvement: American College of Rheumatology 20% improvement criteria (ACR20) · patients with rheumatoid arthritis

Celecoxib showed no clear difference in clinical improvement: American College of Rheumatology 20%… compared with traditional NSAIDs (moderate certainty).

1 finding from 1 review

Celecoxib vs NSAIDs

Pain A 0 t o 100 visual or numerical scale, where 0 equals no pain at all and 100 is the worst pain imaginable · patients with rheumatoid arthritis
1 finding from 1 review