MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low
MMP-9 location/depth · Human carious dentin
Opposite effect directions were reported for MMP-9 by lesion depth or location (very low certainty).
1 finding from 1 review
no estimate extracted
3 studies
Very low
MMP-2 location/presence · Human carious dentin
No effect direction was found for MMP-2 by lesion depth or location (very low certainty).
1 finding from 1 review
no estimate extracted
4 studies
Very low
MMP-8 location/presence · Human carious dentin
Evidence on MMP-8 by lesion depth or location was very low certainty.
1 finding from 1 review
MMP-8 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-8 may be higher before than after cavity sealing, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-9 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-9 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 expression/activity · Human ex vivo carious dentin under sealed cavities
MMP-2 shows no difference before vs after cavity sealing; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-8 location/depth · Human ex vivo carious dentin
MMP-8 showed no statistical difference by lesion location; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 location/depth · Human ex vivo carious dentin
No clear direction of MMP-2 presence by lesion depth/location was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-20 location/depth (outer vs inner) · Human ex vivo carious dentin
MMP-20 probably decreases in outer compared with inner carious dentin (moderate certainty).
1 finding from 1 review
MMP-9 location/depth · Human ex vivo carious dentin
No clear direction of MMP-9 expression by lesion depth/location was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth
Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).
1 finding from 1 review
RR 0.23 [0.08, 0.69]
2 studies
GRADE not reported
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Partial caries removal reduced the reported risk of pulp exposure versus complete caries removal in primary teeth (RR 0.24; ungraded).
1 finding from 1 review
RR 0.24 [0.06, 0.90]
262 participants
GRADE not reported
Pulpal disease (signs/symptoms of pulp necrosis) · Children with dentine caries in primary and permanent teeth
The reported estimate did not show a clear difference in pulpal disease after partial versus complete caries removal (ungraded).
1 finding from 1 review
RR 0.27 [0.05, 1.60]
3 studies
GRADE not reported
Bacterial collagenolytic protease gene expression · Coronal dentin and enamel caries samples
Genes encoding collagenases and other proteases were overrepresented in dentin caries compared with enamel caries.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
Biodentine may increase pulpotomy success versus calcium hydroxide at marginal significance (ungraded).
1 finding from 1 review
OR 6.03 [0.97, 37.6]
2 studies
GRADE not reported
Tooth discoloration · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
More tooth discoloration was observed with MTA than with Biodentine, but odds ratios were implausibly large and not pooled (3 RCTs; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
MTA and Biodentine performed comparably for clinical and radiographic success (5 RCTs, not pooled; ungraded).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; the 7-second etching arm had a lower tabulated failure rate.
1 finding from 1 review
Pulp exposure rate · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal was associated with a lower mean pulp exposure rate than conventional removal (1.2% vs 8.1%), but the difference was not statistically significant (Wilcoxon, p = 0.068); certainty of evidence was not graded.
1 finding from 1 review
Mean pulp-exposure percentage (unweighted study-level mean, 4 studies) MIT 1.2% vs CT 8.1% (Wilcoxon = 0.0, p = 0.068; not statistically significant)
4 studies · 791 participants
GRADE not reported