Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

92 questions · 93 findings · 12 reviews · Schizophrenia

No studies found 15 · 16.1%GRADE not reported 11 · 11.8%Very low 43 · 46.2%Low 12 · 12.9%Moderate 12 · 12.9%High 0 · 0%

CHLORPROMAZINE vs QUETIAPINE

Global state: No clinically significant response (as defined by the original studies) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in no significant clinical response: short term (up to 6 months) compared with QUETIAPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs OLANZAPINE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes adverse effects: any observed extrapyramidal symptoms ‐ short term… compared with OLANZAPINE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RISPERIDONE

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes adverse effects: any observed extrapyramidal symptoms ‐ short term… compared with RISPERIDONE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Global state: not improved ‐ short‐term GAF · patients with schizophrenia

CHLORPROMAZINE may leads to lower global state: Not improved (short term) compared with RESERPINE (low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Mental state: Not improved (paranoid distortion) Multidimentional Scale for Rating Psychiatric Patients (short term) · patients with schizophrenia

It is very uncertain whether CHLORPROMAZINE changes mental state: Not improved (paranoid distortion) Multidimentional… compared with RESERPINE (very low certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Functioning: not improved occupational adjustment (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in functioning: not improved occupational adjustment (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review

CHLORPROMAZINE vs RESERPINE

Adverse events ‐ toxic reaction (short term) · patients with schizophrenia

CHLORPROMAZINE showed no clear difference in adverse events ‐ toxic reaction (short term) compared with RESERPINE (moderate certainty).

1 finding from 1 review