What do systematic reviews say?

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 66.57 [13.5, 328.28]
  2 studies · 547 participants
  Moderate

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 547 participants
  Moderate

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Summary of Findings Table ‐ IncobotulinumtoxinA 20U probably leads to higher physician assessment of success by analysing scores and scales compared with placebo (moderate certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 134.62 [19.05, 951.45]
  2 studies · 547 participants
  Moderate

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

Summary of Findings Table ‐ IncobotulinumtoxinA 20U showed no clear difference in total adverse events compared with placebo (low certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 1.17 [0.9, 1.53]
  2 studies · 547 participants
  Low

Summary of Findings Table ‐ IncobotulinumtoxinA 20U vs placebo

The review found no eligible studies for this question.

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher participant assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 21.1 [11.31, 39.34]
  2 studies · 683 participants
  Moderate

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 716 participants
  Moderate

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher physician assessment of success by analysing scores and scales ‐ 4… compared with placebo (moderate certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 23.4 [12.56, 43.61]
  2 studies · 683 participants
  Moderate

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher total adverse events compared with placebo (moderate certainty).

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  RR 2.23 [1.46, 3.4]
  2 studies · 716 participants
  Moderate

Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo

• Botulinum toxin type A for facial wrinkles 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Moderate