Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 78 findings · 13 reviews · Headline outcomes only

No studies found 10 · 12.8%GRADE not reported 2 · 2.6%Very low 26 · 33.3%Low 20 · 25.6%Moderate 12 · 15.4%High 8 · 10.3%

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Overall survival at 5‐year · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in overall survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Event‐free survival · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Treatment‐related mortality · women with early poor prognosis breast cancer

High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Second cancers at 4 ‐ 9‐year median · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with at least 1 bleeding episode · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one bleeding episode compared with placebo (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Number of participants with severe or life‐threatening bleeding · People with chronic bone marrow failure

Thrombopoietin mimetic showed no clear difference in number of participants with at least one severe or life‐threatening… compared with placebo (low certainty).

1 finding from 1 review

Thrombopoietin mimetics vs placebo

Proportion of patients receiving platelets · People with chronic bone marrow failure

Thrombopoietin mimetic probably leads to lower proportion of participants receiving a platelet transfusion compared with placebo (moderate certainty).

1 finding from 1 review