Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 5 reviews · Neonatal

No studies found 17 · 54.8%GRADE not reported 0 · 0%Very low 10 · 32.3%Low 4 · 12.9%Moderate 0 · 0%High 0 · 0%

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available] · prevention of sepsis and necrotizing enterocolitis in preterm infants

Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Necrotising enterocolitis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in any necrotizing Enterocolitis (NEC) compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review