Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 38 findings · 4 reviews

No studies found 6 · 15.8%GRADE not reported 0 · 0%Very low 16 · 42.1%Low 8 · 21.1%Moderate 8 · 21.1%High 0 · 0%

Antiplatelet drug vs control

Recurrent ischaemic or unknown stroke during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes recurrent ischaemic/unknown stroke during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Major extracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes major extracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Antiplatelet drug vs control

Complete recovery from stroke (post hoc) · acute ischaemic stroke

Antiplatelet drug probably leads to higher complete recovery from stroke (post hoc) compared with control (moderate certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

All‐cause mortality (up to 30 days) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (up to 30 days) compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring transfusion of blood products (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring transfusion of blood products (intraoperatively… compared with discontinuation of antiplatelet therapy (moderate certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring further surgery (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring further surgery (intraoperatively and… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Ischaemic events: peripheral thrombosis, cerebral myocardial infarction (within 30 days of surgery) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in ischaemic events: peripheral thrombosis, cerebral myocardial… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review