What do systematic reviews say?

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 795 participants
  Moderate

Cetirizine 10 mg/d vs placebo (4‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

Cetirizine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  RR 1.11 [0.5, 2.45]
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 84 participants
  Low

Cetirizine 10 mg/d vs placebo (4‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg may leads to higher complete suppression of urticaria Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 2.72 [1.51, 4.91]
  2 studies · 178 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Rupatadine 10 to 20 mg vs placebo

Rupatadine 10 to 20 mg may leads to higher good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.35 [1.03, 1.77]
  1 study · 245 participants
  Low

Loratadine 10 mg vs placebo

Loratadine 10 mg showed no clear difference in good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.86 [0.91, 3.79]
  2 studies · 124 participants
  Low

Loratadine 10 mg vs cetirizine (antihistamine)

Loratadine 10 mg showed no clear difference in complete cessation of urticaria Global assessment of symptom scores compared with cetirizine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.05 [0.76, 1.43]
  2 studies · 103 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.91 [0.78, 1.06]
  2 studies · 369 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.64, 1.71]
  3 studies · 410 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.86 [0.64, 1.16]
  3 studies · 316 participants
  Very low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.55, 1.42]
  3 studies · 314 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.38 [0.04, 3.6]
  2 studies · 267 participants
  Low

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg showed no clear difference in adverse events leading to withdrawal compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3 [0.68, 13.22]
  3 studies · 389 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes proportion of participants with at least 50% improvement in QoL:… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3.21 [0.32, 32.33]
  2 studies · 252 participants
  Very low

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.78, 1.39]
  1 study · 161 participants
  Moderate

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.96, 1.24]
  1 study · 160 participants
  Moderate