> 50% reduction in depressive symptoms · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants showed no clear difference in severity of depression dichotomous measures ‐ >50% reduction in… compared with placebo (low certainty).
1 finding from 1 review
Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use
It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).
1 finding from 1 review
Benzodiazepine discontinuation, longest · adults who withdraw from chronic benzodiazepine use
Tricyclic antidepressants may leads to higher benzodiazepine discontinuation, longest compared with placebo (low certainty).
1 finding from 1 review
Benzodiazepine withdrawal symptoms, end of intervention · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
Benzodiazepine withdrawal symptoms, longest · adults who withdraw from chronic benzodiazepine use
1 finding from 1 review
Leaving the study early · patients with the treatment of cocaine dependence
Amantidine showed no clear difference in dropouts compared with antidepressants (moderate certainty).
1 finding from 1 review
Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence
Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).
1 finding from 1 review
Abstinence · patients with the treatment of cocaine dependence
Amantidine may leads to lower abstinence (objective) N of subjects abstinent at the end of the study compared with antidepressants (low certainty).
1 finding from 1 review