Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

300 questions · 309 findings · 25 reviews · Headline outcomes only

No studies found 53 · 17.2%GRADE not reported 11 · 3.6%Very low 41 · 13.3%Low 94 · 30.4%Moderate 80 · 25.9%High 30 · 9.7%

Higher‐dose anticoagulants vs lower‐dose anticoagulants

Necessity for additional respiratory support · people hospitalised with COVID‐19

It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).

1 finding from 1 review

Anticoagulant vs placebo or no intervention

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · people with distal DVT

Anticoagulant leads to higher clinically relevant non‐major bleeding ( compared with no intervention or placebo (high certainty).

1 finding from 1 review