Cochrane · systematic review · CD013422
Treatment of distal deep vein thrombosis
Kirkilesis, G, Kakkos, SK, Bicknell, C, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
11
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 2 · 14.3%Very low 0 · 0%Low 6 · 42.9%Moderate 0 · 0%High 5 · 35.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anticoagulant compared to no intervention or placebo for distal deep vein thrombosis treatment
Population: people with distal DVT
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of VTE ( Anticoagulant vs no intervention or placebo | RR 0.34 [0.15, 0.77] | 5 studies · 496 participants | High |
Major bleeding ( Anticoagulant vs no intervention or placebo | RR 0.76 [0.13, 4.62] | 4 studies · 480 participants | Low Downgraded: imprecision |
Recurrence of DVT ( Anticoagulant vs no intervention or placebo | RR 0.25 [0.1, 0.67] | 5 studies · 496 participants | High |
PE ( Anticoagulant vs no intervention or placebo | RR 0.81 [0.18, 3.59] | 4 studies · 480 participants | Low Downgraded: imprecision |
Clinically relevant non‐major bleeding ( Anticoagulant vs no intervention or placebo | RR 3.34 [1.07, 10.46] | 2 studies · 322 participants | High |
Overall mortality ( Anticoagulant vs no intervention or placebo | RR 3.2 [0.13, 77.69] | 3 studies · 430 participants | Low Downgraded: imprecision |
Mortality related to PE ( Anticoagulant vs no intervention or placebo | no estimate extracted | 3 studies · 430 participants | Ungraded |
Anticoagulation for three months or more compared to anticoagulation for six weeks for distal deep vein thrombosis treatment
Population: people with distal DVT
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Recurrence of VTE ( Anticoagulation for three months or more vs anticoagulation | RR 0.42 [0.26, 0.68] | 3 studies · 736 participants | High |
Major bleeding ( Anticoagulation for three months or more vs anticoagulation | RR 3.42 [0.36, 32.35] | 2 studies · 389 participants | Low Downgraded: imprecision |
Recurrence of DVT ( Anticoagulation for three months or more vs anticoagulation | RR 0.32 [0.16, 0.64] | 2 studies · 389 participants | High |
PE ( Anticoagulation for three months or more vs anticoagulation | RR 1.05 [0.19, 5.88] | 2 studies · 389 participants | Low Downgraded: imprecision |
Clinically relevant non‐major bleeding ( Anticoagulation for three months or more vs anticoagulation | RR 1.76 [0.9, 3.42] | 2 studies · 389 participants | Low Downgraded: imprecision |
Overall mortality Anticoagulation for three months or more vs anticoagulation | no estimate extracted | NR | No studies |
Mortality related to PE ( Anticoagulation for three months or more vs anticoagulation | no estimate extracted | 1 study · 197 participants | Ungraded |