Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

76 questions · 76 findings · 7 reviews · Headline outcomes only

No studies found 5 · 6.6%GRADE not reported 0 · 0%Very low 5 · 6.6%Low 47 · 61.8%Moderate 19 · 25%High 0 · 0%

T‐cell antibody induction vs corticosteroid induction

Infection Number of participants who experienced at least 1 episode of infection · liver transplant recipients

T‐cell antibody induction showed no clear difference in infection Number of participants who experienced at least 1 episode… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Hepatitis C recurrence Number of participants diagnosed with hepatitis C virus recurrence · liver transplant recipients

T‐cell antibody induction showed no clear difference in hepatitis C recurrence Number of participants diagnosed with… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Graft loss including death · liver transplant recipients

T‐cell antibody induction may leads to lower graft loss including death Graft loss including death at latest compared with placebo/no intervention (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Acute rejection · liver transplant recipients

T‐cell antibody induction probably leads to lower acute rejection Number of participants who experienced at least 1… compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

Polyclonal T‐cell antibody induction vs interleukin‐2 receptor antagonist induction

Bronchiolitis obliterans syndrome · lung transplant recipients

Polyclonal T‐cell antibody induction showed no clear difference in bronchiolitis obliterans syndrome compared with interleukin‐2 receptor antagonist induction (moderate certainty).

1 finding from 1 review

Monoclonal antibody vs polyclonal antibody

Post‐transplantation lymphoproliferative disorder Number of participants diagnosed with PTLD · heart transplant recipients

Monoclonal antibody showed no clear difference in post‐transplantation lymphoproliferative disorder Number of… compared with polyclonal antibody (low certainty).

1 finding from 1 review