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Evidence found and GRADE certainty

92 questions · 92 findings · 9 reviews · Headline outcomes only

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No studies found 45 · 48.9%GRADE not reported 1 · 1.1%Very low 4 · 4.3%Low 21 · 22.8%Moderate 14 · 15.2%High 7 · 7.6%

Lesinurad 200 mg plus allopurinol vs placebo plus allopurinol

Proportion with complete resolution of a target tophus · participants with tophi in gout

Lesinurad 200 mg plus allopurinol showed no clear difference in proportion with complete resolution of a target tophus compared with placebo plus allopurinol (moderate certainty).

1 finding from 1 review

Lesinurad 400 mg plus allopurinol vs placebo plus allopurinol

Proportion with complete resolution of a target tophus · participants with tophi in gout

Lesinurad 400 mg plus allopurinol showed no clear difference in proportion with complete resolution of a target tophus compared with placebo plus allopurinol (moderate certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)

All‐cause mortality at last · people with liver metastases

Summary of Findings Table ‐ Electrocoagulation in combination with… may leads to lower all‐cause mortality at last compared with control (vehicle solution of allopurinol by mouth) (low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation in combination with allopurinol or with dimethyl sulphoxide vs control (vehicle solution of allopurinol by mouth)

Post‐operative deaths · people with liver metastases

It is very uncertain whether summary of Findings Table ‐ Electrocoagulation in combination with… changes post‐operative deaths compared with control (vehicle solution of allopurinol by mouth) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)

All‐cause mortality at last · people with liver metastases

It is very uncertain whether summary of Findings Table ‐ Electrocoagulation alone changes all‐cause mortality at last compared with control (vehicle solution of allopurinol by mouth) (very low certainty).

1 finding from 1 review

Summary of Findings Table ‐ Electrocoagulation alone vs control (vehicle solution of allopurinol by mouth)

Post‐operative deaths · people with liver metastases

It is very uncertain whether summary of Findings Table ‐ Electrocoagulation alone changes post‐operative deaths compared with control (vehicle solution of allopurinol by mouth) (very low certainty).

1 finding from 1 review