Findings

What do systematic reviews say?

30 questions · 30 findings · 4 reviews

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No studies found 2 · 6.7%GRADE not reported 2 · 6.7%Very low 16 · 53.3%Low 1 · 3.3%Moderate 9 · 30%High 0 · 0%

Paroxetine vs agomelatine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1074 participants
Moderate

Paroxetine vs agomelatine

Failure to complete ‐ any cause ‐ · patients with depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 0.99 [0.57, 1.71]
1 study · 284 participants
Moderate

Paroxetine vs agomelatine

Participants with at least some Side Effects · patients with depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with agomelatine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.6 [0.99, 2.59]
1 study · 284 participants
Moderate

Paroxetine vs agomelatine

Failure to respond at endpoint (6‐12 weeks) · patients with depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with agomelatine (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.25 [0.78, 2.01]
1 study · 284 participants
Moderate

Paroxetine vs agomelatine

Failure to respond at 1‐4 weeks · patients with depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs agomelatine

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with agomelatine (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.44 [0.99, 2.09]
1 study · 515 participants
Low

Fluoxetine vs agomelatine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1213 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.31 [0.89, 1.94]
2 studies · 785 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.08 [0.41, 2.88]
2 studies · 785 participants
Moderate

Fluoxetine vs agomelatine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with agomelatine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.51 [0.74, 3.07]
2 studies · 785 participants
Moderate