Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

704 questions · 710 findings · 81 reviews · Headline outcomes only

No studies found 227 · 32%GRADE not reported 38 · 5.4%Very low 178 · 25.1%Low 178 · 25.1%Moderate 80 · 11.3%High 9 · 1.3%

Topical active treatment in combination with moisturiser vs topical active treatment alone

Number of participants reporting an adverse event · people with eczema

It is very uncertain whether topical active treatment in combination with moisturiser changes number of participants reporting an adverse event compared with topical active treatment alone (very low certainty).

1 finding from 1 review

Active treatment vs observation

Eradication of MRSA · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen

Active treatment showed no clear difference in eradication of MRSA: number of participants that were MRSA‐negativea compared with observation only (low certainty).

1 finding from 1 review

Active treatment vs observation

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Ear drops (any active treatment) vs no treatment

Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal

Ear drops (any active treatment) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with no treatment (low certainty).

1 finding from 1 review

Ear drops (any active treatment) vs ear drops (water or saline)

Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal

Ear drops (any active treatment) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with ear drops (water or saline) (low certainty).

1 finding from 1 review

Interventions delivered by dental professionals vs control

Smoking cessation · participants who used tobacco products

It is very uncertain whether interventions delivered by dental professionals changes multi‐session behavioural support versus usual care, brief advice,… compared with control (very low certainty).

1 finding from 1 review

Intervention not reported

Primary outcome 1: participant‐ or parent‐rated symptoms of eczema (SCORAD part C) at the end of active treatment Visual analogue scale for itch and sleep disturbance ranging from 0 to 10 for each symptom and combined ranging from 0 to 20. The hig... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review

Intervention not reported

Primary outcome 1: participant‐ or parent‐rated global change in eczema symptoms at the end of active treatment (binary outcome) Change in risk for worsened/unchanged eczema Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema

The intervention showed no clear difference in primary outcome 1: participant‐ or parent‐rated global change in… (low certainty).

1 finding from 1 review