Topical active treatment in combination with moisturiser vs topical active treatment alone
Participant satisfaction · people with eczema
1 finding from 1 review
- no estimate extracted2 studies · 201 participantsLow
Findings
What do systematic reviews say?
841 questions · 868 findings · 102 reviews
No studies found 276 · 31.8%GRADE not reported 111 · 12.8%Very low 197 · 22.7%Low 187 · 21.5%Moderate 88 · 10.1%High 9 · 1%
Topical active treatment in combination with moisturiser vs topical active treatment alone
Number of participants reporting an adverse event · people with eczema
It is very uncertain whether topical active treatment in combination with moisturiser changes number of participants reporting an adverse event compared with topical active treatment alone (very low certainty).
1 finding from 1 review
- RR 0.39 [0.13, 1.19]1 study · 125 participantsVery low
Topical active treatment in combination with moisturiser vs topical active treatment alone
Change from baseline in disease severity as assessed by the investigators · people with eczema
1 finding from 1 review
- no estimate extracted3 studies · 192 participantsModerate
Topical active treatment in combination with moisturiser vs topical active treatment alone
Number of participants who experienced a flare · people with eczema
Topical active treatment in combination with moisturiser may leads to lower number of participants who experienced a flare compared with topical active treatment alone (low certainty).
1 finding from 1 review
- RR 0.43 [0.2, 0.93]1 study · 105 participantsLow
Topical active treatment in combination with moisturiser vs topical active treatment alone
Change from baseline in health‐related quality of life · people with eczema
1 finding from 1 review
- no estimate extracted2 studies · 67 participantsLow
Vehicle treatment + daily moisturiser vs fluticasone propionate twice weekly + daily moisturiser
Change in use of topical active treatment ‐ not measured · people with eczema
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Active treatment vs observation
Eradication of MRSA · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
Active treatment showed no clear difference in eradication of MRSA: number of participants that were MRSA‐negativea compared with observation only (low certainty).
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyOR 1.72 [0.65, 4.55]2 studies · 68 participantsLow
Active treatment vs observation
Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Active treatment vs observation
Quality of life: CFRSD‐CRISS symptom score · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 45 participantsLow
Active treatment vs observation
FEV1 % predicted: absolute change from baseline · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 58 participantsVery low
Active treatment vs observation
Change in weight (kg) · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 38 participantsVery low
Active treatment vs observation
Exacerbation frequency · adults or children with positive microbiological isolate of MRSA from a respiratory tract specimen
1 finding from 1 review
- Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes onlyno estimate extracted1 study · 32 participantsVery low
Ear drops (any active treatment) vs no treatment
Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal
Ear drops (any active treatment) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with no treatment (low certainty).
1 finding from 1 review
- RR 4.091 study · 73 participantsLow
Ear drops (any active treatment) vs no treatment
Discomfort/pain · adults and children with ear wax requiring removal
Ear drops (any active treatment) may leads to lower adverse effects: discomfort, irritation or pain compared with no treatment (low certainty).
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Ear drops (any active treatment) vs ear drops (water or saline)
Proportion of patients (or ears) with complete clearance of ear wax · adults and children with ear wax requiring removal
Ear drops (any active treatment) may leads to higher proportion of patients (or ears) with complete clearance of ear wax compared with ear drops (water or saline) (low certainty).
1 finding from 1 review
- RR 1.473 studies · 213 participantsLow
Ear drops (any active treatment) vs ear drops (water or saline)
Discomfort/pain · adults and children with ear wax requiring removal
Ear drops (any active treatment) may leads to lower adverse effects: discomfort, irritation or pain compared with ear drops (water or saline) (low certainty).
1 finding from 1 review
- no estimate extracted10 participantsLow
Intervention not reported
No active treatment (No direct RCT) · people with liver cirrhosis and ascites
It is very uncertain whether the intervention changes no active treatment (No direct RCT) (very low certainty).
1 finding from 1 review
- Treatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyHR 1.66 [0.46, 6.99]Studies not reportedVery low
Interventions delivered by dental professionals vs control
Smoking cessation · participants who used tobacco products
It is very uncertain whether interventions delivered by dental professionals changes multi‐session behavioural support versus usual care, brief advice,… compared with control (very low certainty).
1 finding from 1 review
- Interventions for tobacco cessation delivered by dental professionals 2021 · Cochrane Headline outcomes onlyRR 1.9 [1.17, 3.11]7 studies · 2639 participantsVery low
Macrolide+tetracycline vs macrolides
Change in baseline trough FEV1 · patients with chronic obstructive pulmonary disease
1 finding from 1 review
- Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes onlyno estimate extracted1 study · 182 participantsVery low
Intervention not reported
Primary outcome 1: participant‐ or parent‐rated symptoms of eczema (SCORAD part C) at the end of active treatment Visual analogue scale for itch and sleep disturbance ranging from 0 to 10 for each symptom and combined ranging from 0 to 20. The hig... · male and female patients 0 to 55 years of age with physician‐diagnosed eczema
1 finding from 1 review
- no estimate extracted13 studies · 754 participantsModerate