Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · children with eczema
Cetirizine 0.5 mg/kg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (18‐month intervention) (moderate certainty).
1 finding from 1 review
Physician‐assessed changes in clinical signs · children with eczema
1 finding from 1 review
Secondary outcome: quality of life · children with eczema
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Secondary outcome: clinical flare · children with eczema
1 finding from 1 review
Clearing or excellent improvement · people with discoid lupus erythematosus
1 finding from 1 review
At least 50% reduction in erythema · people with discoid lupus erythematosus
1 finding from 1 review
Quality of life measure · people with discoid lupus erythematosus
The review found no eligible studies for this question.
1 finding from 1 review
Relapse · people with discoid lupus erythematosus
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events of medication, leading to discontinuation or significant morbidity · people with discoid lupus erythematosus
1 finding from 1 review
Adverse effects: allergy to local anaesthetic · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Adverse effects: pain following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
2 findings from 1 review
SoF: Not measured.
0 studies
No studies found
SoF: See comment (orphan study; unclear whether data relate to just solution deposition; SDs not reported); 18 participants, 36 interventions (1 study). Not pooled/graded.
1 study · 18 participants
GRADE not reported
Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Speed of onset of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
SoF: See comment, not estimable (orphan study; duration of follow-up not reported); 100 participants, 100 interventions (1 study). Not pooled/graded.
1 study · 100 participants
GRADE not reported
Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
1 finding from 1 review
Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine may leads to higher speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Duration of anaesthesia · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found
Success of local anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
0.5% bupivacaine, 1:200,000 epinephrine showed no clear difference in success of local anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).
1 finding from 1 review
Success of local anaesthesia (soft tissue, self-reported; 100% success in all studies) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
'Other comparisons with 100% success': IANB - Sampaio 2012 35/35 vs 35/35; Fernandez 2005 39/39 vs 39/39. Both formulations 100% successful; no meta-analysis (no difference).
2 studies · 74 participants
GRADE not reported
Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
The review found no eligible studies for this question.
1 finding from 1 review
SoF: Not measured.
0 studies
No studies found