Ketamine vs placebo
- Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
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It is very uncertain whether ketamine changes acceptability: total dropouts№ of participants: 201(6 RCTs) compared with placebo (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether salbutamol changes need for continuous positive airway pressure (yes/no) compared with placebo/no treatment (very low certainty).
It is very uncertain whether salbutamol changes need for mechanical ventilation (yes/no) compared with placebo/no treatment (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether salbutamol changes pneumothorax (yes/no) compared with placebo/no treatment (very low certainty).
It is very uncertain whether antihypertensive therapy changes all‐cause mortality compared with placebo or no treatment (very low certainty).
It is very uncertain whether antihypertensive therapy changes cardiovascular events compared with placebo or no treatment (very low certainty).
It is very uncertain whether antihypertensive therapy changes total serious adverse events compared with placebo or no treatment (very low certainty).
It is very uncertain whether antihypertensive therapy changes hospitalisation for heart failure compared with placebo or no treatment (very low certainty).
It is very uncertain whether antihypertensive therapy changes withdrawal due to adverse events compared with placebo or no treatment (very low certainty).
Carisbamate probably leads to higher 50% or greater reduction in seizure frequency (responder rate) compared with placebo (moderate certainty).
It is very uncertain whether carisbamate changes seizure freedom compared with placebo (very low certainty).
It is very uncertain whether carisbamate changes treatment withdrawal for any reason compared with placebo (very low certainty).
It is very uncertain whether carisbamate changes treatment withdrawal due to adverse events compared with placebo (very low certainty).
Carisbamate showed no clear difference in proportion of participants who experienced atleast 1 adverse event compared with placebo (low certainty).