Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Dactolisib (1 RCT; 62 participants)

It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes dactolisib (1 RCT; 62 participants) compared with placebo (very low certainty).

2 findings from 1 review

Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Everolimus

Estimates of effects, ranking, and certainty of evidence for… probably leads to lower everolimus (3 RCT; 632 participants) compared with placebo (moderate certainty).

4 findings from 1 review
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Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Interferon + SSA (2 RCTs; 171 participants)

It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes interferon + SSA (2 RCTs; 468 participants) compared with placebo (very low certainty).

4 findings from 1 review
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Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Everolimus + SSA (1 RCT; 39 participants)

Estimates of effects, ranking, and certainty of evidence for… may leads to lower everolimus + SSA (3 RCTs; 739 participants) compared with placebo (low certainty).

4 findings from 1 review
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Estimates of effects, ranking, and certainty of evidence for different treatment options vs placebo

Bevacizumab + SSA (1 RCT; 402 participants)

It is very uncertain whether estimates of effects, ranking, and certainty of evidence for… changes bevacizumab + SSA (1 RCT; 402 participants) compared with placebo (very low certainty).

3 findings from 1 review