Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Carisbamate vs placebo

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · people with drug‐resistant focal epilepsy

Carisbamate may leads to higher adverse events: somnolence compared with placebo (low certainty).

1 finding from 1 review

Summary of findings ‐ AZLI vs placebo

Participants hospitalised for respiratory exacerbation · adults and children with CF

Summary of findings ‐ AZLI showed no clear difference in participants hospitalised for respiratory exacerbation compared with placebo (moderate certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs no CPAP

Erectile dysfunction · erectile dysfunction in men with obstructive sleep apnoea
2 findings from 1 review

Continuous positive airway pressure (CPAP) vs phosphodiesterase type 5 inhibitors

Minor adverse events · erectile dysfunction in men with obstructive sleep apnoea

It is very uncertain whether continuous positive airway pressure (CPAP) changes minor adverse events compared with phosphodiesterase type 5 inhibitors (very low certainty).

1 finding from 1 review