Number of pulmonary exacerbations or hospitalisations · children and young adults with CF
High‐dose rhGH showed no clear difference in number of pulmonary exacerbations or hospitalisations compared with standard‐dose rhGH (low certainty).
1 finding from 1 review
Height velocity (cm/year) · children and young adults with CF
1 finding from 1 review
Change in weight (kg) · children and young adults with CF
1 finding from 1 review
QoL · children and young adults with CF
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Fasting blood glucose (mg/dL) · children and young adults with CF
1 finding from 1 review
Number of pulmonary exacerbations or hospitalisations · children and young adults with CF
Standard rhGH showed no clear difference in number of pulmonary exacerbations or hospitalisations compared with placebo (low certainty).
1 finding from 1 review
FEV1 % predicted · children and young adults with CF
1 finding from 1 review
FVC · children and young adults with CF
1 finding from 1 review
Intervention not reported
≥ 50% reduction in seizure frequency (adults) · people with drug‐resistant focal epilepsy
The intervention probably leads to higher ≥ 50% reduction in seizure frequency (adults) (moderate certainty).
1 finding from 1 review
Intervention not reported
≥ 50% reduction in seizure frequency (children aged 6–18 years) · people with drug‐resistant focal epilepsy
The intervention showed no clear difference in ≥ 50% reduction in seizure frequency (children aged 6–18 years) (moderate certainty).
1 finding from 1 review
Intervention not reported
Freedom from seizures · people with drug‐resistant focal epilepsy
The intervention probably leads to higher freedom from seizures (moderate certainty).
1 finding from 1 review
Intervention not reported
Treatment withdrawal (any reason) · people with drug‐resistant focal epilepsy
The intervention showed no clear difference in treatment withdrawal (any reason) (moderate certainty).
1 finding from 1 review
Intervention not reported
Treatment withdrawal (adverse effect) · people with drug‐resistant focal epilepsy
The intervention probably leads to higher treatment withdrawal (adverse effect) (moderate certainty).
1 finding from 1 review
Intervention not reported
Adverse effects · people with drug‐resistant focal epilepsy
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain)
1 finding from 1 review
no estimate extracted
2746 participants
Moderate
FUNCTIONAL LIMITATIONS
1 finding from 1 review
no estimate extracted
2942 participants
Moderate
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale)
1 finding from 1 review
no estimate extracted
6295 participants
Low
FUNCTIONAL LIMITATIONS
1 finding from 1 review
no estimate extracted
6004 participants
Moderate
*The anticipated absolute effects without exercise come from the range of outcomes at
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
12MWT: change from baseline in m walked · children and adults with mucopolysaccharidosis type VI
1 finding from 1 review