Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Intervention not reported

Participants with new need for invasive mechanical ventilation or death · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Participants discharged alive. Participants should be discharged without clinical deterioration or death · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life up to 28 days and longest · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

SAEs during the study period · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Any grade TEAE · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Any grade TRAE · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Discontinuation of study drug due to adverse events · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Admission to hospital or death · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention may leads to lower admission to hospital or death (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Viral clearance at 7 days · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

It is very uncertain whether the intervention changes viral clearance at 7 days (very low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at 14 days · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

It is very uncertain whether the intervention changes viral clearance at 14 days (very low certainty).

1 finding from 1 review

Intervention not reported

Admission to ICU or death · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

All initial symptoms resolved at 28 days, and up to the longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Time to symptom resolution · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life up to 28 days and longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

SAEs during the study period · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention may leads to lower SAEs during the study period (low certainty).

1 finding from 1 review

Intervention not reported

Any grade TEAE · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention showed no clear difference in any grade TEAE (moderate certainty).

1 finding from 1 review

Intervention not reported

Any grade TRAE · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression to severe disease

The intervention probably leads to higher any grade TRAE (moderate certainty).

1 finding from 1 review