Total nocturnal sleep time (minutes) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Difficulty waking in the morning, average of weeks 1 and 2№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Psychomotor vigilance task (PVT) reciprocal of reaction time, change from baseline№ of participants: 10(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Quality of life Functional Outcomes of Sleep Questionnaire · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of participants with any adverse events№ of participants: 10(1 RCT) · idiopathic hypersomnia
Clarithromycin showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).
1 finding from 1 review
OR 0.41 [0.01, 12.64]
Studies not reported
Low
Number of naps/week, week 3№ of participants: 99(2 RCTs) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Clinical Global Impression ‐ Severity (CGI‐S), change from baseline№ of participants: 30(1 RCT) · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Clinical Global Impression ‐ Change (CGI‐C), proportion much improved or very much improved at week 3 № of participants: 70 (1 RCT) · idiopathic hypersomnia
Modafinil probably leads to higher clinical Global Impression ‐ Change (CGI‐C), proportion much… compared with placebo (moderate certainty).
1 finding from 1 review
OR 5.14 [1.76, 15]
Studies not reported
Moderate
improvement in the maintenance of wakefulness test · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
High
Effectiveness · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Number of participants with any adverse events№ of participants: 102(2 RCTs) · idiopathic hypersomnia
Modafinil showed no clear difference in number of participants with any adverse events№ of participants:… compared with placebo (low certainty).
1 finding from 1 review
OR 1.68 [0.28, 9.94]
Studies not reported
Low
Daytime sleepiness (ESS): change from baseline. · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Sleepiness · idiopathic hypersomnia
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction
Beta‐blockers may leads to lower cardiovascular mortality (RR) compared with placebo or no treatment (low certainty).
1 finding from 1 review
Quality of life (MLHFQ): from 0 to 105 · patients with chronic heart failure with preserved ejection fraction
1 finding from 1 review
Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction
Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction
Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in heart failure hospitalisation (RR) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction
1 finding from 1 review
All‐cause mortality (RR) · patients with chronic heart failure with preserved ejection fraction
Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Quality of life (MLHFQ): from 0 to 105 · patients with chronic heart failure with preserved ejection fraction
1 finding from 1 review