Modafinil vs placebo: Clinical Global Impression ‐ Change (CGI‐C), proportion much improved or very much improved at week 3 № of participants: 70 (1 RCT)
Modafinil probably leads to higher clinical Global Impression ‐ Change (CGI‐C), proportion much… compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Modafinil vs placebo Clinical Global Impression ‐ Change (CGI‐C), proportion much improved or very much improved at week 3 № of participants: 70 (1 RCT) · idiopathic hypersomnia Modafinil probably leads to higher clinical Global Impression ‐ Change (CGI‐C), proportion much… compared with placebo (moderate certainty). Medications for daytime sleepiness in individuals with idiopathic hypersomnia (2021) · Cochrane Headline outcomes only | OR 5.14 [1.76, 15] | Not reported | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Medications for daytime sleepiness in individuals with idiopathic hypersomnia 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.