Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Boost vs no boost

Disease-free survival (new disease, progression or mortality) · breast‐conserving radiotherapy for breast cancer

Boost showed no clear difference in disease‐free survival: disease progression/mortality at 5 years compared with no boost (low certainty).

1 finding from 1 review

Boost vs no boost

Cosmesis · breast‐conserving radiotherapy for breast cancer

Boost may leads to higher cosmesis, panel scored: fair or poor compared with no boost (low certainty).

2 findings from 1 review

Boost vs no boost

Subgroup analysis: local control ‐ > 40 years old, recurrence at 5 years · breast‐conserving radiotherapy for breast cancer

Boost leads to lower subgroup analysis: local control ‐ > 40 years old, recurrence at 5… compared with no boost (high certainty).

1 finding from 1 review

Hand‐assisted laparoscopic repair vs EVAR

Major complications ‐ lower limb ischaemia (up to 12 months) · People undergoing elective abdominal aortic aneurysm repair

Hand‐assisted laparoscopic repair showed no clear difference in major complications ‐ lower limb ischaemia (up to 12 months) compared with EVAR (low certainty).

1 finding from 1 review

Neuraxial vs general anaesthesia

Return of patient to their own home · Patients with hip fracture repair

It is very uncertain whether neuraxial block changes return of patient to their own home compared with general anaesthesia (very low certainty).

1 finding from 1 review