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Evidence found and GRADE certainty

3,971 questions · 9,849 findings · 853 reviews

No studies found 1,150 · 11.7%GRADE not reported 3,387 · 34.4%Very low 1,963 · 19.9%Low 1,809 · 18.4%Moderate 1,207 · 12.3%High 333 · 3.4%

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T allele of AMELX rs17878486 vs C allele of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs17878486 and dental caries susceptibility (T vs C model: OR 2.87, 95% CI 0.35-23.23) in the Control group: Caries-free subgroup; certainty not graded.

6 findings from 1 review
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CT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (CT vs CC model: OR 1.20, 95% CI 0.65-2.22) in the Ethnicity: Caucasian subgroup; certainty not graded.

2 findings from 1 review

GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of ENAM rs1264848 and dental caries susceptibility (GG vs AA + AG model: OR 1.09, 95% CI 0.53-2.23) in the Ethnicity: Mixed subgroup; certainty not graded.

2 findings from 1 review

Multiple LTF gene variants (joint / gene-based) vs Caries-free controls

Dental caries · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

A gene-based analysis indicated that multiple LTF variants were jointly associated with dental caries risk (weighted TPM P = 0.0007; no pooled effect estimate; ungraded).

1 finding from 1 review

TT genotype of AMELX rs2106416 vs CC + CT genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC + CT model: OR 1.67, 95% CI 0.44-6.34) in the Ethnicity: Caucasian subgroup; certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Australia, the pooled prevalence of primary-teeth caries in children was 28.5% (95% CI 20.3 to 38.5); certainty not graded.

1 finding from 1 review

AG + GG genotype (G-allele carriers) of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.69, 95% CI 0.78-3.68) in the Ethnicity: Mixed subgroup; certainty not graded.

5 findings from 1 review
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