Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Infiltration injection local anaesthetic vs no treatment or placebo

Physiological parameters (cardiac/respiratory events; type and volume of GA drug) · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…
1 finding from 1 review

Branemark Mark II turned titanium screws vs ITI TPS hollow titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Branemark Mark II turned titanium screws showed no clear difference in implant failure compared with ITI TPS hollow titanium screws; GRADE not reported.

1 finding from 1 review

Surgical anchorage (mini-screw or mid-palatal implant) vs Conventional anchorage (headgear, transpalatal/palatal arch, etc.)

Economic factors · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)

The review found no eligible studies for this question.

1 finding from 1 review

Powered toothbrush (any mode of action) vs Manual toothbrush

Cost (relative cost of powered vs manual) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

The review found no eligible studies for this question.

1 finding from 1 review

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Prosthesis failure · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus

Maxillary sinus lift (augmentation) with long implants showed no clear difference in prosthesis failure compared with short implants (5 to 8.5 mm) without sinus augmentation (moderate certainty).

1 finding from 1 review

Intraligamental injection local anaesthetic vs no treatment

Participant satisfaction · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…

The review found no eligible studies for this question.

1 finding from 1 review

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

Partial graft loss · Patients with insufficient bone below the maxillary sinus requiring dental implants

Bone graft with platelet-rich plasma (PRP) showed no clear difference in partial graft loss compared with bone graft without PRP; GRADE not reported.

1 finding from 1 review

Zygomatic implants without bone grafts (as a complete alternative to any bone augmentation procedure) vs Conventional dental implants in augmented maxillae

Patient perceived satisfaction (denture preference) · Participants with an atrophic maxilla who cannot be rehabilitated with conventional dental implants due to lack of bone (including…

The review found no eligible studies for this question.

1 finding from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Plaque · Children aged 4 to 12 years attending primary school

Primary school-based behavioural intervention (both oral hygiene and… showed no clear difference in plaque indices (permanent and deciduous teeth) compared with no intervention or delayed intervention (non-intervention control;… (low certainty).

1 finding from 1 review
  • SoF (Plaque indices, follow-up 3 to 15 months): 'All 3 RCTs showed a reduction in plaque in the intervention group compared to control group'; 827 participants (3 RCTs); GRADE low; comment 'Data not suitable for…
    3 studies · 827 participants
    Low

Orthodontic distalising appliance (intraoral or extraoral) vs no intervention

Non-compliance rate of the intervention · Children and adolescents (aged 16 years or less at the start of treatment) undergoing orthodontic treatment to distalise upper first…

The review found no eligible studies for this question.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Damage to the teeth (e.g. tooth decay) · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

1 finding from 1 review

Partial caries removal (single stage; residual dentinal caries sealed into the tooth definitively) vs Complete caries removal

Pulp exposure during caries removal · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth

Partial caries removal (single stage; residual dentinal caries… probably leads to lower pulp exposure during caries removal compared with complete caries removal (moderate certainty).

1 finding from 1 review