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Evidence found and GRADE certainty

4,783 questions · 10,022 findings · 882 reviews

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No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Glutamate modulators vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

Opioid antagonists vs placebo

Treatment responseaClinical Global Impressions ‐ Improvement Scale (CGI‐I) (no. of responders) & NIMH Trichotillomania Severity Scale (NIMH‐TSS) (no. of responders as > 50% reduction) · adults with trichotillomania

It is very uncertain whether opioid antagonists changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Dropouts due to adverse events · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children with trichotillomania

Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review