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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

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Review versions

1,956 questions in 143 reviews · Musculoskeletal

current versions

No studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Balneotherapy vs placebo Pain intensity VAS, 0‐100 (no pain to worst pain ever) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 45 participants	Very low
Additional radon in carbon dioxide baths vs carbon dioxide baths only Improvement More than 1 category change in pain intensity on 4‐point scale (no pain/sporadic/daily/continuous) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	RR 1.38 [0.64, 2.93]	1 study · 60 participants	Low
Additional radon in carbon dioxide baths vs carbon dioxide baths only Improvement More than 1 category change in pain intensity on 4‐point scale (no pain/sporadic/daily/continuous) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	RR 2.29 [1.1, 4.74]	1 study · 60 participants	Low
Additional radon in carbon dioxide baths vs carbon dioxide baths only Physical disability Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Additional radon in carbon dioxide baths vs carbon dioxide baths only Tender joints Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Additional radon in carbon dioxide baths vs carbon dioxide baths only Swollen joints Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Additional radon in carbon dioxide baths vs carbon dioxide baths only Withdrawal due to serious adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Additional radon in carbon dioxide baths vs carbon dioxide baths only Adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs drug treatment Pain intensity VAS, 0‐100 mm (no pain to worst pain ever) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 57 participants	Very low
Balneotherapy vs drug treatment Improvement Global improvement on 5‐point scale (very good/good/fair/poor/very poor) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	RR 2.35 [1.44, 3.83]	1 study · 57 participants	Very low
Balneotherapy vs drug treatment Physical disability Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs placebo Improvement Yes/no based on 5 outcome measures (> 30% reduction in number of swollen joints, > 30% reduction in number of tender joints, > 20% improvement in patient VAS for severity of pain and > 20% improvement in physician VAS) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	RR 0.96 [0.54, 1.7]	1 study · 45 participants	Very low
Balneotherapy vs drug treatment Tender joints Number of tender joints Scale from 0 to 28 · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 57 participants	Very low
Balneotherapy vs drug treatment Swollen joints Number of swollen joints Scale from 0 to 28 · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 57 participants	Very low
Balneotherapy vs drug treatment Withdrawal due to serious adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs drug treatment Adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs placebo Physical disability Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs placebo Tender joints Number of painful joints Scale from 0 to 28 · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 45 participants	Very low
Balneotherapy vs placebo Swollen joints Number of swollen joints Scale from 0 to 28 · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	1 study · 45 participants	Very low
Balneotherapy vs placebo Withdrawal due to serious adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Balneotherapy vs placebo Adverse events Not reported · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	NR	No studies
Additional radon in carbon dioxide baths vs carbon dioxide baths only Pain intensity VAS, 0‐100 mm (no pain to worst pain ever) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	2 studies · 194 participants	Moderate
Additional radon in carbon dioxide baths vs carbon dioxide baths only Pain intensity VAS, 0‐100 mm (no pain to worst pain ever) · participants with rheumatoid arthritis Balneotherapy (or spa therapy) for rheumatoid arthritis (2015) · Cochrane	no estimate extracted	2 studies · 194 participants	Moderate
Psychological therapies vs usual care Functioning as assessed post‐intervention Fibromyalgia Impact Questionnaire. Scale from: 0 to 100 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Low
Biofeedback vs usual care Adverse events post‐intervention ‐ not reported · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	No studies
Mindfulness vs usual care Functioning as assessed post‐intervention Fibromyalgia Impact Questionnaire. Scale from: 0 to 100 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	2 studies · 128 participants	Low
Mindfulness vs usual care Pain as assessed post‐intervention Visual analog scale 0 to 100. Scale from: 0 to 10. · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	2 studies · 128 participants	Low
Mindfulness vs usual care Mood as assessed post‐intervention State Trait Anxiety Inventory State Scale. Scale from: 0 to 60. · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	3 studies · 218 participants	Moderate
Mindfulness vs usual care All cause attrition post‐intervention Number of people withdrawing from the study before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 1.07 [0.67, 1.72]	3 studies · 195 participants	Moderate
Mindfulness vs usual care Adverse events post‐intervention ‐ not reported · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	No studies
Movement therapies vs usual care Functioning as assessed post‐intervention Fibromyalgia Impact Questionnaire ‐ Revised. Scale from: 0 to 100. · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	4 studies · 143 participants	Very low
Movement therapies vs usual care Pain as assessed post‐intervention 10 point visual analog scale. Scale from: 0 to 10 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	1 study · 28 participants	Very low
Movement therapies vs usual care Mood as assessed post‐intervention Center for Epidemiologic Studies Depression Scale. Scale from: 0 to 60 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	1 study · 29 participants	Very low
Movement therapies vs usual care All cause attrition post‐intervention Number of people withdrawing from the study before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 1.95 [1.13, 3.38]	5 studies · 240 participants	Very low
Psychological therapies vs usual care Pain as assessed post‐intervention 100 point visual analog scale. Scale from: 0 to 100 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Low
Movement therapies vs usual care Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 4.62 [0.23, 93.72]	1 study · 98 participants	Very low
Relaxation vs usual care Functioning as assessed post‐intervention Fibromyalgia Impact Questionnaire. Scale from: 0 to 80 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Very low
Relaxation vs usual care Pain as assessed post‐intervention Short Form ‐ McGill Pain Questionnaire Total Score. Scale from: 0 to 78 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Very low
Relaxation vs usual care Mood as assessed post‐intervention Center for Epidemiologic Disease Depression Scale. Scale from: 0 to 60 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Very low
Relaxation vs usual care All cause attrition post‐intervention Number of people withdrawing from the study before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 4.4 [0.59, 33.07]	NR	Very low
Relaxation vs usual care Adverse events post‐intervention ‐ not reported · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	No studies
Psychological therapies vs usual care Mood as assessed post‐intervention State Trait Anxiety Inventory ‐ State Scale. Scale from: 20 to 80 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	NR	Low
Psychological therapies vs usual care All cause attrition post‐intervention Number of people withdrawing from the study before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 1.38 [1.12, 1.69]	NR	Very low
Psychological therapies vs usual care Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 0.38 [0.06, 2.5]	NR	Low
Biofeedback vs usual care Functioning as assessed post‐intervention Fibromyalgia Impact Questionnaire Revised. Scale from: 0 to 100 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	2 studies · 106 participants	Very low
Biofeedback vs usual care Pain as assessed post‐intervention 100 point visual analog scale. Scale from: 0 to 100 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	1 study · 65 participants	Very low
Biofeedback vs usual care Mood as assessed post‐intervention The Symptom Checklist‐90 Revised. Scale from: 0 to 90 · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	no estimate extracted	2 studies · 104 participants	Very low
Biofeedback vs usual care All cause attrition post‐intervention Number of people withdrawing from the study before completing the intervention · patients with fibromyalgia Mind and body therapy for fibromyalgia (2015) · Cochrane	RR 4.08 [1.43, 11.62]	3 studies · 125 participants	Very low
Mobile bearing vs fixed bearing prosthesis Pain ‐ measured as KSS pain Knee Society Score, subscore pain. Scale from 0 (severe pain) to 50 (no pain) · patients with posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients… Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for… (2015) · Cochrane	no estimate extracted	11 studies · 1531 participants	Moderate
Mobile bearing vs fixed bearing prosthesis Function ‐ measured as KSS function Knee Society Score, function. Scale from 0 to 100 (higher scores indicates better function) · patients with posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients… Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for… (2015) · Cochrane	no estimate extracted	14 studies · 1865 participants	Low