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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,105 questions in 84 reviews · Metabolic and Endocrine Disorders
current versionsNo studies 434 · 39.3%Ungraded 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Proportion of women having their first OGTT after giving birth a) Postal reminder to woman and physician b) Postal reminder to woman c) Postal reminder to physician · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | RR 4.23 [1.85, 9.71] | 1 study · 116 participants | Low |
Intervention NR Proportion of women having a blood glucose test other than an OGTT after giving birth: fasting blood glucose a) Postal reminder to woman and physician b) Postal reminder to woman c) Postal reminder to physician · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | RR 1.57 [1.01, 2.44] | 1 study · 116 participants | Low |
Intervention NR Proportion of women diagnosed with type 2 diabetes or showing impaired glucose tolerance or impaired fasting glucose after giving birth · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Diabetes‐associated morbidity · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Costs or other measures of resource use · women with previous gestational diabetes mellitus Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR All‐cause mortality Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cancer occurrence Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | 152 participants | Low |
Intervention NR Pressure symptoms/cosmetic complaints Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Nodule volume reduction ≥ 50% Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Socioeconomic effects Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane | no estimate extracted | NR | No studies |
Intensive glycaemic control vs conventional glycaemic control All‐cause mortality · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 1 [0.92, 1.08] | 24 studies · 34325 participants | Moderate |
Intensive glycaemic control vs conventional glycaemic control Cardiovascular mortality · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 1.06 [0.94, 1.21] | 22 studies · 34177 participants | Moderate |
Intensive glycaemic control vs conventional glycaemic control Non‐fatal myocardial infarction · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 0.87 [0.77, 0.98] | 14 studies · 30417 participants | Moderate |
Intensive glycaemic control vs conventional glycaemic control Non‐fatal stroke · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 1 [0.84, 1.19] | 13 studies · 30003 participants | Moderate |
Intensive glycaemic control vs conventional glycaemic control Amputation of lower extremity · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 0.65 [0.45, 0.94] | 11 studies · 11200 participants | Low |
Intensive glycaemic control vs conventional glycaemic control End‐stage renal disease · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 0.87 [0.71, 1.06] | 8 studies · 28145 participants | Moderate |
Intensive glycaemic control vs conventional glycaemic control Hypoglycaemia ‐ Severe hypoglycaemia · participants with type 2 diabetes mellitus Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane | RR 2.18 [1.53, 3.11] | 17 studies · 28794 participants | High |
Intervention NR Diabetes and non‐diabetes related morbidity · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Death from any cause · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse effects [ · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | 1 study · 56 participants | Very low |
Intervention NR Health‐related quality of life · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Glycaemic control (fructosamine levels) [ · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | 1 study · 56 participants | Very low |
Intervention NR Economic data · peri‐ or postmenopausal women with type 1 diabetes mellitus Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 5 studies · 2113 participants | Moderate |
Intervention NR Death from any cause [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 16 studies · 3578 participants | High |
Intervention NR Depression [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 6 studies · 2273 participants | Moderate |
Intervention NR Adverse effects [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 16 studies · 3578 participants | High |
Intervention NR HbA1c [%] [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 1 study · 11 participants | Moderate |
Intervention NR Economic data [ · participants with type 2 diabetes mellitus Interventions Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 1 study · 761 participants | Low |
Intervention NR All‐cause mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 1.46 [0.87, 2.45] | 2 studies · 553 participants | Low |
Intervention NR Non‐fatal macrovascular outcomes 1. Composite a. Intervention vs metformin [1a. 6 months to 4 years] b. Intervention vs thiazolidinediones [1b. 52 weeks to 4 years] c. Intervention vs meglitinide [1c. 12 months to 15 months]2. Non‐fatal myocardial... · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 0.67 [0.48, 0.93] | 1 study · 3 participants | Low |
Intervention NR Microvascular outcomes · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events 1. All adverse events 2. Drop‐outs due to adverse events 3. Severe hypoglycaemia a. Intervention vs placebo [1a. 24 weeks] [2a. 24 weeks to 56 weeks] b. Intervention vs metformin [1b. 6 months to 4 years] [2b. 24 weeks to 4 years] [... · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 0.91 [0.51, 1.62] | 1 study · 2 participants | Low |
Intervention NR Cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years] b. Intervention vs insulin [6 years to 10 years] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 1.02 [0.72, 1.45] | 6 studies · 4192 participants | Low |
Intervention NR Health‐related quality of life a. Intervention vs thiazolidinediones [12 months] b. Intervention vs insulin [6 years] c. Intervention vs alpha‐glucosidase inhibitors [12 months] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | 1 study · 35 participants | Very low |
Intervention NR All‐cause mortality · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cardiovascular mortality · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Macrovascular outcomes · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Microvascular outcomes · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Interventions vs thiazolidinediones [1. 6 months to 12 months] [2. 24 weeks to 52 weeks] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 0.88 [0.78, 0.99] | 1 study · 3 participants | Low |
Intervention NR Cardiovascular mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 2.63 [1.32, 5.22] | 2 studies · 553 participants | Low |
Intervention NR Cancer · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 1.08 [0.81, 1.45] | 1 study · 2 participants | Low |
Intervention NR Microvascular outcomes · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 0.81 [0.29, 2.27] | 2 studies · 1944 participants | Low |
Intervention NR Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Intervention vs alpha‐glucosidase inhibitors [30 weeks] · participants with type 2 diabetes mellitus Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane | RR 0.63 [0.52, 0.76] | 1 study · 2 participants | Low |