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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

1,105 questions in 84 reviews · Metabolic and Endocrine Disorders

current versions
No studies 434 · 39.3%Ungraded 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Proportion of women having their first OGTT after giving birth a) Postal reminder to woman and physician b) Postal reminder to woman c) Postal reminder to physician · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
RR 4.23 [1.85, 9.71]1 study · 116 participantsLow
Intervention NR
Proportion of women having a blood glucose test other than an OGTT after giving birth: fasting blood glucose a) Postal reminder to woman and physician b) Postal reminder to woman c) Postal reminder to physician · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
RR 1.57 [1.01, 2.44]1 study · 116 participantsLow
Intervention NR
Proportion of women diagnosed with type 2 diabetes or showing impaired glucose tolerance or impaired fasting glucose after giving birth · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Diabetes‐associated morbidity · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Costs or other measures of resource use · women with previous gestational diabetes mellitus
Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for… (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
All‐cause mortality
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cancer occurrence
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extracted152 participantsLow
Intervention NR
Pressure symptoms/cosmetic complaints
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Nodule volume reduction ≥ 50%
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Socioeconomic effects
Chinese herbal medicines for benign thyroid nodules in adults (2014) · Cochrane
no estimate extractedNRNo studies
Intensive glycaemic control vs conventional glycaemic control
All‐cause mortality · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 1 [0.92, 1.08]24 studies · 34325 participantsModerate
Intensive glycaemic control vs conventional glycaemic control
Cardiovascular mortality · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 1.06 [0.94, 1.21]22 studies · 34177 participantsModerate
Intensive glycaemic control vs conventional glycaemic control
Non‐fatal myocardial infarction · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 0.87 [0.77, 0.98]14 studies · 30417 participantsModerate
Intensive glycaemic control vs conventional glycaemic control
Non‐fatal stroke · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 1 [0.84, 1.19]13 studies · 30003 participantsModerate
Intensive glycaemic control vs conventional glycaemic control
Amputation of lower extremity · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 0.65 [0.45, 0.94]11 studies · 11200 participantsLow
Intensive glycaemic control vs conventional glycaemic control
End‐stage renal disease · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 0.87 [0.71, 1.06]8 studies · 28145 participantsModerate
Intensive glycaemic control vs conventional glycaemic control
Hypoglycaemia ‐ Severe hypoglycaemia · participants with type 2 diabetes mellitus
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes… (2013) · Cochrane
RR 2.18 [1.53, 3.11]17 studies · 28794 participantsHigh
Intervention NR
Diabetes and non‐diabetes related morbidity · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Death from any cause · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse effects [ · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extracted1 study · 56 participantsVery low
Intervention NR
Health‐related quality of life · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Glycaemic control (fructosamine levels) [ · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extracted1 study · 56 participantsVery low
Intervention NR
Economic data · peri‐ or postmenopausal women with type 1 diabetes mellitus
Hormone replacement therapy for women with type 1 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted5 studies · 2113 participantsModerate
Intervention NR
Death from any cause [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted16 studies · 3578 participantsHigh
Intervention NR
Depression [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted6 studies · 2273 participantsModerate
Intervention NR
Adverse effects [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted16 studies · 3578 participantsHigh
Intervention NR
HbA1c [%] [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted1 study · 11 participantsModerate
Intervention NR
Economic data [ · participants with type 2 diabetes mellitus Interventions
Computer‐based diabetes self‐management interventions for adults with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted1 study · 761 participantsLow
Intervention NR
All‐cause mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 1.46 [0.87, 2.45]2 studies · 553 participantsLow
Intervention NR
Non‐fatal macrovascular outcomes 1. Composite a. Intervention vs metformin [1a. 6 months to 4 years] b. Intervention vs thiazolidinediones [1b. 52 weeks to 4 years] c. Intervention vs meglitinide [1c. 12 months to 15 months]2. Non‐fatal myocardial... · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 0.67 [0.48, 0.93]1 study · 3 participantsLow
Intervention NR
Microvascular outcomes · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events 1. All adverse events 2. Drop‐outs due to adverse events 3. Severe hypoglycaemia a. Intervention vs placebo [1a. 24 weeks] [2a. 24 weeks to 56 weeks] b. Intervention vs metformin [1b. 6 months to 4 years] [2b. 24 weeks to 4 years] [... · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 0.91 [0.51, 1.62]1 study · 2 participantsLow
Intervention NR
Cancer a. Intervention vs thiazolidinediones [52 weeks to 4 years] b. Intervention vs insulin [6 years to 10 years] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 1.02 [0.72, 1.45]6 studies · 4192 participantsLow
Intervention NR
Health‐related quality of life a. Intervention vs thiazolidinediones [12 months] b. Intervention vs insulin [6 years] c. Intervention vs alpha‐glucosidase inhibitors [12 months] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extracted1 study · 35 participantsVery low
Intervention NR
All‐cause mortality · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cardiovascular mortality · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Macrovascular outcomes · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Microvascular outcomes · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Interventions vs thiazolidinediones [1. 6 months to 12 months] [2. 24 weeks to 52 weeks] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 0.88 [0.78, 0.99]1 study · 3 participantsLow
Intervention NR
Cardiovascular mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 2.63 [1.32, 5.22]2 studies · 553 participantsLow
Intervention NR
Cancer · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Non‐fatal macrovascular outcomes 1. Composite 2. Non‐fatal myocardial infarction Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 1.08 [0.81, 1.45]1 study · 2 participantsLow
Intervention NR
Microvascular outcomes · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cancer Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 0.81 [0.29, 2.27]2 studies · 1944 participantsLow
Intervention NR
Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Intervention vs alpha‐glucosidase inhibitors [30 weeks] · participants with type 2 diabetes mellitus
Sulphonylurea monotherapy for patients with type 2 diabetes mellitus (2013) · Cochrane
RR 0.63 [0.52, 0.76]1 study · 2 participantsLow