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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,395 questions in 172 reviews · Gut
current versionsNo studies 420 · 17.5%Ungraded 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Rifaximin vs placebo Adverse events · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.5 [0.72, 3.14] | 1 study · 18 participants | Very low |
Lactobacillus GG vs placebo Clinical remission · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Lactobacillus GG vs placebo Clinical improvement · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 3 [0.14, 65.9] | 1 study · 20 participants | Very low |
Lactobacillus GG vs placebo Maintenance of clinical remission · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Lactobacillus GG vs placebo No episodes acute pouchitis · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs metronidazole Clinical improvement · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Lactobacillus GG vs placebo Adverse events · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Glutamine vs butyrate Clinical remission · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Glutamine vs butyrate Clinical improvement · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Glutamine vs butyrate Maintenance of clinical remission · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.8 [0.63, 5.16] | 1 study · 19 participants | Very low |
Glutamine vs butyrate No episodes acute pouchitis · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Glutamine vs butyrate Adverse events · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bismuth enema vs placebo Clinical remission · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bismuth enema vs placebo Clinical improvement · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1 [0.5, 1.98] | 1 study · 40 participants | Very low |
Bismuth enema vs placebo Maintenance of clinical remission · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bismuth enema vs placebo No episodes acute pouchitis · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs metronidazole Maintenance of clinical remission · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bismuth enema vs placebo Adverse events · Patients with chronic pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 0.71 [0.27, 1.88] | 1 study · 40 participants | Very low |
De Simone Formulation vs placebo Clinical remission · Patients with chronic pouchitis or ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs placebo Clinical improvement · Patients with chronic pouchitis or ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs placebo Maintenance of clinical remission · Patients with chronic pouchitis or ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 20.24 [4.28, 95.81] | 2 studies · 76 participants | Low |
De Simone Formulation vs placebo No episodes of acute pouchitis · Patients with chronic pouchitis or ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.5 [1.02, 2.21] | 1 study · 40 participants | Low |
De Simone Formulation vs placebo Adverse events · Patients with chronic pouchitis or ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 2.43 [0.11, 55.89] | 2 studies · 76 participants | Low |
De Simone Formulation vs no treatment Clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs no treatment Clinical improvement · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs no treatment Maintenance of clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs no treatment No episodes of acute pouchitis · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.1 [0.89, 1.36] | 1 study · 28 participants | Very low |
Ciprofloxacin vs metronidazole No episodes acute pouchitis · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
De Simone Formulation vs no treatment Adverse events · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bifidobacterium longum vs placebo Clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bifidobacterium longum vs placebo Clinical improvement · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bifidobacterium longum vs placebo Maintenance of clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Bifidobacterium longum vs placebo No episodes of acute pouchitis · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.43 [0.66, 3.11] | 1 study · 12 participants | Very low |
Bifidobacterium longum vs placebo Adverse events · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Allopurinol vs placebo Clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Allopurinol vs placebo Clinical improvement · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Allopurinol vs placebo Maintenance of clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Allopurinol vs placebo No episodes of acute pouchitis · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.43 [0.66, 3.11] | 1 study · 184 participants | Low |
Ciprofloxacin vs metronidazole Adverse events · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 0.18 [0.01, 2.98] | 1 study · 16 participants | Very low |
Allopurinol vs placebo Adverse events · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tinidazole vs placebo Clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tinidazole vs placebo Clinical improvement · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tinidazole vs placebo Maintenance of clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Tinidazole vs placebo No episodes of acute pouchitis · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.38 [0.83, 2.31] | 1 study · 38 participants | Very low |
Tinidazole vs placebo Adverse events · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Adalimumab vs placebo Clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Adalimumab vs placebo Clinical improvement · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 1.17 [0.36, 3.76] | 1 study · 13 participants | Low |
Adalimumab vs placebo Maintenance of clinical remission · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Adalimumab vs placebo No of episodes of acute pouchitis · Patients with ileal pouch‐anal anastomosis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | no estimate extracted | NR | No studies |
Metronidazole vs budesonide enema Clinical remission · Patients with acute pouchitis Treatment and prevention of pouchitis after ileal pouch‐anal anastomosis for chronic ulcerative colitis (2019) · Cochrane | RR 0.86 [0.37, 1.96] | 1 study · 26 participants | Very low |