Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

IFN‐α + PUVA vs PUVA

Improvement of quality of life · people with mycosis fungoides

The review found no eligible studies for this question.

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Common adverse effects ‐ Photosensitivity (Time point of measurement: up to 16 weeks) · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in common adverse effects ‐ Photosensitivity (Time point of… compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Complete response · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in complete response (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Objective response rate · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in objective response rate (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

IFN‐α + acitretin vs IFN‐α + PUVA

Adverse event (flu‐like symptoms) · people with mycosis fungoides

IFN‐α + acitretin showed no clear difference in common adverse effects ‐ Flu‐like symptoms (Time point of… compared with IFN‐α + PUVA (low certainty).

1 finding from 1 review

IFN‐α + acitretin vs IFN‐α + PUVA

Complete response · people with mycosis fungoides

IFN‐α + acitretin may leads to lower complete response (Time point of measurement: up to 48 weeks or… compared with IFN‐α + PUVA (low certainty).

1 finding from 1 review

IFN‐α + PUVA vs PUVA

Complete response · people with mycosis fungoides

IFN‐α + PUVA showed no clear difference in complete response (CR) compared with PUVA alone (low certainty).

1 finding from 1 review

Extracorporeal photopheresis vs PUVA

Complete response · people with mycosis fungoides

It is very uncertain whether extracorporeal photopheresis changes complete response (Time point of measurement: three months of PUVA… compared with PUVA (very low certainty).

1 finding from 1 review

Extracorporeal photopheresis vs PUVA

Objective response rate · people with mycosis fungoides

It is very uncertain whether extracorporeal photopheresis changes objective response rate (Time point of measurement: three months of… compared with PUVA (very low certainty).

1 finding from 1 review