Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,126 questions · 1,225 findings · 111 reviews

No studies found 235 · 19.2%GRADE not reported 260 · 21.2%Very low 207 · 16.9%Low 271 · 22.1%Moderate 177 · 14.4%High 75 · 6.1%

Staple food fortified with vitamin A plus other micronutrients vs no intervention

Subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L or less) · general population over 2 years of age

It is very uncertain whether staple food fortified with vitamin A plus other micronutrients changes subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L… compared with no intervention (very low certainty).

1 finding from 1 review

Staple food fortified with vitamin A plus other micronutrients vs same unfortified staple foods

Subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L or less) · general population over 2 years of age

Staple foods fortified with vitamin A plus other micronutrients probably leads to lower subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L… compared with same unfortified staple foods (moderate certainty).

1 finding from 1 review

Vitamin C vs placebo

Incidence of pneumonia Defined as patient admitted to hospital with a diagnosis of pneumonia Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes incidence of pneumonia Defined as patient admitted to hospital with… compared with placebo (very low certainty).

1 finding from 1 review

Vitamin C vs placebo

Adverse effects (urticaria) Defined as participants reporting urticaria (hives) Dose: 2 g per day · school‐aged children (6 to 15 years) and marine corps recruits (mean age 18.5 years)

It is very uncertain whether vitamin C changes adverse effects (urticaria) Defined as participants reporting… compared with placebo (very low certainty).

1 finding from 1 review