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Evidence found and GRADE certainty

377 questions · 736 findings · 60 reviews · Dental caries

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No studies found 17 · 2.3%GRADE not reported 563 · 76.5%Very low 39 · 5.3%Low 47 · 6.4%Moderate 50 · 6.8%High 20 · 2.7%

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Patient satisfaction · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…
1 finding from 1 review
  • Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
    Abu-Naba'a 2003 reported participants' state of anxiety, comparing ozone treatment with traditional dental interventions (injection, drilling, filling); because no participant was randomised between ozone and drilling…
    1 study
    GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Further conventional dental treatment (filling and drilling) (binary yes/no) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review
  • Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
    Data were not provided by any study on the number of lesions requiring restorations to 6 months or later; no data on any further conventional treatment or other dental interventions.
    Studies not reported
    No studies found

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Costs · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Pain (assessed by the patient) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Caries progression/regression (clinical severity index, log(e) ECM and log(e) DIAGNOdent scores) · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…
1 finding from 1 review
  • Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes
    6 and 12 months
    No consistent trend of benefit or harm following ozone was seen across the outcome measures in any of the three studies; analyses were conducted at the lesion level (not independent of the person), so data were not…
    3 studies · 137 participants
    GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

Time to intervention · People of any age with caries (including demineralisation in non-cavitated carious lesions); the caries may affect any single tooth…

The review found no eligible studies for this question.

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

In the single study reporting it, caries incidence was 0% in both the laser-alone and acid-etching groups (ungraded, single study).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants

At 12 months, Er:YAG laser combined with acid-etching significantly improved sealant retention versus acid-etching alone (OR 0.39, 95% CI 0.19 to 0.80, favouring laser+acid; ungraded, single study).

4 findings from 1 review
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Laser enamel preparation vs Enameloplasty

Any planned outcome (sealant retention, caries, etc.) · Patients with premolars/molars requiring pit-and-fissure sealants

No eligible studies compared laser preparation with enameloplasty for fissure sealant placement (evidence gap).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Acceptability · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Both laser and acid-etching preparation were well accepted by patients (VAS, P = 1.000; ungraded, single study).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Clinical (chair-side) time · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

Laser conditioning was reported to take less chair-side time than acid-etching in the studies that measured it, but times were not pooled (ungraded, narrative).

1 finding from 1 review

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

At 18 months, laser preparation alone did not differ significantly from acid-etching for sealant retention (OR 0.82, 95% CI 0.23 to 2.85; ungraded, single study, high risk of bias).

6 findings from 1 review
Show 3 more findings

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Physiological stress indicators (heart rate, oxygen saturation) · Children (ages 6-12) receiving pit-and-fissure sealants

Heart rate and oxygen saturation did not differ significantly between laser-plus-acid and acid-etching (ungraded, single study).

1 finding from 1 review

Laser enamel preparation vs Air abrasion

Any planned outcome (sealant retention, caries, etc.) · Patients with premolars/molars requiring pit-and-fissure sealants

No eligible studies compared laser preparation with air abrasion for fissure sealant placement (evidence gap).

1 finding from 1 review

Laser enamel preparation (with or without acid-etching) vs Acid-etching (phosphoric acid)

Adverse events · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants

No adverse events were reported in any included study (ungraded, narrative).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Development of >=1 new carious lesion (caries incidence) · Children (high caries risk) with permanent molars requiring pit-and-fissure sealants

Caries incidence was 10% with laser-plus-acid versus 22% with acid-etching at 18 months, a non-significant difference (ungraded, single study).

1 finding from 1 review

Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid)

Dental anxiety (subjective and objective scores) · Children (ages 6-12) receiving pit-and-fissure sealants

Er:YAG laser preparation added to acid-etching did not increase children's dental anxiety versus acid-etching alone (P > 0.05; ungraded, single study).

1 finding from 1 review