Findings

What do systematic reviews say?

601 questions · 608 findings · 50 reviews · Kidney and Transplant

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No studies found 127 · 20.9%GRADE not reported 6 · 1%Very low 189 · 31.1%Low 184 · 30.3%Moderate 87 · 14.3%High 15 · 2.5%

Pharmacological interventions vs placebo

Doxepin Itch relief · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Topical treatments vs placebo

Capsaicin cream VAS and Duo’s score · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
Moderate

Topical treatments vs placebo

Pramoxine lotion VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Topical treatments vs placebo

Calcineurin inhibitor VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 80 participants
Very low

Topical treatments vs placebo

Dead Sea lotion 1 to 5 severity score · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Topical treatments vs placebo

Cromolyn cream VAS (0 to 5 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Pharmacological interventions vs placebo

Ondansetron VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 183 participants
High

Topical treatments vs placebo

Baby oil Itch Severity Scale(0 to 21) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 125 participants
Low

Topical treatments vs placebo

L‐arginine salve 0 to 3 severity score · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Topical treatments vs placebo

Polyunsaturated fatty acids VAS (0 to 10 cm) Duo score · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 78 participants
Low

Pharmacological interventions vs placebo

Kappa‐opioid agonist VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 661 participants
High

Pharmacological interventions vs placebo

Mu‐opioid antagonist VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 62 participants
Low

Pharmacological interventions vs placebo

Nalbuphine VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 179 participants
Low

Pharmacological interventions vs placebo

Cromolyn VAS(0 to 10 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Pharmacological interventions vs placebo

Nicotinamide VAS(0 to 5 cm) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Pharmacological interventions vs placebo

EPO Duo score(0 to 40) · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Pharmacological interventions vs placebo

Cholestyramine 0 to 3 severity scale · uraemic pruritus

1 finding from 1 review

Interventions for itch in people with advanced chronic kidney disease 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 15 participants
Low

ACUTE: Serelaxin vs placebo

Death (any cause) · heart failure with chronic kidney disease

ACUTE: Serelaxin showed no clear difference in death (any cause) compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.59 [0.34, 1.02]
2 studies · 1395 participants
Low

CHRONIC: ACEi or ARB vs placebo

Death (any cause) ( · heart failure with chronic kidney disease

CHRONIC: ACEi or ARB showed no clear difference in death (any cause) ( compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.85 [0.7, 1.02]
4 studies · 5003 participants
Low

CHRONIC: ACEi or ARB vs placebo

All cardiovascular death · heart failure with chronic kidney disease

CHRONIC: ACEi or ARB showed no clear difference in cardiovascular death ( compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for heart failure in people with chronic kidney disease 2020 · Cochrane Headline outcomes only
RR 0.81 [0.64, 1.01]
2 studies · 1368 participants
Low