What do systematic reviews say?

Acupuncture vs psychological therapy

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 497 participants
  Low

Acupuncture vs psychological therapy

Acupuncture showed no clear difference in adverse events measured during study treatment compared with psychological therapy (low certainty).

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  RR 0.62 [0.29, 1.33]
  1 study · 453 participants
  Low

Acupuncture vs psychological therapy

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs psychological therapy

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Exercise vs light therapy

• Exercise for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

CBT vs treatment

• Cognitive behavioural therapy for anxiety disorders in children and adolescents 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 228 participants
  Low
• Cognitive behavioural therapy for anxiety disorders in children and adolescents 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 98 participants
  Moderate

CBT vs WAIT LIST

• Cognitive behavioural therapy for anxiety disorders in children and adolescents 2020 · Cochrane Headline outcomes only
  no estimate extracted
  35 studies · 2137 participants
  Low
• Cognitive behavioural therapy for anxiety disorders in children and adolescents 2015 · Cochrane Headline outcomes only
  no estimate extracted
  30 studies · 1394 participants
  Low
• Cognitive behavioural therapy for anxiety disorders in children and adolescents 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 186 participants
  Low

Alpha‐blockers vs placebo

The review found no eligible studies for this question.

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Comparison 12: SNRIs vs placebo

It is very uncertain whether comparison 5: SNRIs changes treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (very low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.98 [0.88, 1.1]
  2 studies · 687 participants
  Very low

Comparison 13: SSRIs vs placebo

Comparison 6: SSRIs probably leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (moderate certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.66 [0.59, 0.74]
  8 studies · 1078 participants
  Moderate

Comparison 13: SSRIs vs placebo

Comparison 6: SSRIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.98 [0.96, 1]
  14 studies · 2399 participants
  Moderate

Comparison 7: TCAs vs placebo

Comparison 7: TCAs may leads to lower treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.6 [0.38, 0.96]
  1 study · 40 participants
  Low

Comparison 7: TCAs vs placebo

Comparison 7: TCAs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.92 [0.81, 1.05]
  3 studies · 141 participants
  Moderate

Alpha‐blockers vs placebo

Comparison 1: Alpha‐blockers showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (moderate certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.99 [0.91, 1.08]
  1 study · 304 participants
  Moderate

Antipsychotics vs placebo

It is very uncertain whether comparison 2: Antipsychotics changes treatment efficacy ‐ treatment response, as measured by the Global… compared with placebo (very low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.51 [0.16, 1.67]
  2 studies · 43 participants
  Very low

Antipsychotics vs placebo

Comparison 2: Antipsychotics showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.98 [0.92, 1.05]
  5 studies · 348 participants
  Low

MAOIs vs placebo

The review found no eligible studies for this question.

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

MAOIs vs placebo

Comparison 3: MAOIs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 1.14 [0.9, 1.43]
  1 study · 37 participants
  Low

Comparison 9: NaSSAs vs placebo

Comparison 4: NaSSAs may leads to lower treatment efficacy ‐ Treatment response, as measured by the Global… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.45 [0.22, 0.94]
  1 study · 26 participants
  Low

Comparison 9: NaSSAs vs placebo

Comparison 4: NaSSAs showed no clear difference in treatment tolerability, as measured by Dropouts due to adverse… compared with placebo (low certainty).

• Pharmacotherapy for post traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
  RR 0.87 [0.68, 1.11]
  1 study · 36 participants
  Low