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What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

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No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Methotrexate vs placebo

Health‐related quality of life ‐ not reported · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in radiographic progression ‐ not measured · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs other DMARDs

Disease response (leflunomide) · psoriatic arthritis

It is very uncertain whether methotrexate changes disease response (leflunomide) compared with other DMARDs (very low certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (subgroup genotypic) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (subgroup genotypic) compared with standard methods versus placebo (low certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (subgroup phenotypic) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (subgroup phenotypic) compared with standard methods versus placebo (low certainty).

1 finding from 1 review

Rapid susceptibility methods vs standard methods versus placebo

Mortality (without stewardship) · people with bloodstream infections

Rapid susceptibility methods showed no clear difference in mortality (without stewardship) compared with standard methods versus placebo (low certainty).

1 finding from 1 review