Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Mortality: lung cancer · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower lung cancer‐related mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

All‐cause mortality ‐ planned time points · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower all‐cause mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Overdiagnosis Time point: ≥ 10 years from randomisation excluding CXR trials  · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in overdiagnosis Time point: ≥ 10 years from randomisation excluding… compared with no LDCT screening (low certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Any death postsurgery Time point: 6 years to 9 years from randomisation · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in any death postsurgery Time point: 6 years to 9 years from… compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

Health‐related quality of life ‐ anxiety Time point: 10 months to 5 years from randomisation Measured by different scales · healthy adults

Low‐dose computed tomography (LDCT) screening showed no clear difference in health‐related quality of life ‐ anxiety Time point: 10 months to 5… compared with no LDCT screening (low certainty).

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, surface index D(M)FS · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFS at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

Caries increment, tooth index D(M)FT · Children with high risk of dental decay

It is very uncertain whether slow-release fluoride device (fluoride glass beads) changes increase in DMFT at 2 years compared with baseline compared with placebo or usual care (control) (very low certainty).

1 finding from 1 review