Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,057 questions · 1,077 findings · 32 reviews · Skin

No studies found 395 · 36.7%GRADE not reported 89 · 8.3%Very low 172 · 16%Low 177 · 16.4%Moderate 191 · 17.7%High 53 · 4.9%

Irradiation with UV light: local narrow‐band UVB vs local PUVA

Primary: investigator‐rated good/excellent control of symptoms · people with hand eczema unresponsive to clobetasol propionate

Irradiation with UV light: local narrow‐band UVB showed no clear difference in primary: investigator‐rated good/excellent control of symptoms compared with local PUVA (moderate certainty).

1 finding from 1 review

Irradiation with UV light: local narrow‐band UVB vs local PUVA

Primary: adverse events ‐ reported adverse events, mainly erythema · people with hand eczema unresponsive to clobetasol propionate

Irradiation with UV light: local narrow‐band UVB probably leads to higher primary: adverse events ‐ reported adverse events, mainly erythema compared with local PUVA (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs mometasone furoate ointment

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic relapsing dyshidrotic eczema on hands

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs mometasone furoate ointment

Primary: participant‐rated good/excellent control of symptoms Not measured · people with moderate to severe chronic relapsing dyshidrotic eczema on hands

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment probably leads to higher primary: investigator‐rated good/excellent control of symptoms compared with vehicle (moderate certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Primary: participant‐rated good/excellent control of symptoms · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam probably leads to higher primary: participants with self‐rated good/excellent control of… compared with vehicle foam (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Primary: participant‐rated good/excellent control of symptoms Not measured · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Primary: adverse events ‐ burning/itching at application site · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment showed no clear difference in primary: adverse events ‐ burning/itching at application site compared with vehicle (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Secondary: investigator‐rated reduction in severity ‐ Not measured · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

The review found no eligible studies for this question.

1 finding from 1 review

Oral retinoids: alitretinoin 30 mg vs placebo

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: investigator‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review

Oral retinoids: alitretinoin 30 mg vs placebo

Primary: participant‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: participant‐rated good/excellent control of symptoms… compared with placebo (high certainty).

1 finding from 1 review

Oral retinoids: alitretinoin 30 mg vs placebo

Adverse effects: headache · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 30 mg leads to higher primary: adverse events ‐ headache Folluw‐up: 48 weeks to 72 weeks compared with placebo (high certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Number of participants with any adverse event (primary tolerability outcome) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with vehicle foam (moderate certainty).

1 finding from 1 review

Oral retinoids: alitretinoin 30 mg vs placebo

Secondary: investigator‐rated reduction in severity in TLSSc and mTLSSd · people with moderate to severe chronic hand eczema

The review found no eligible studies for this question.

1 finding from 1 review

Oral retinoids: alitretinoin 10 mg vs placebo

Primary: investigator‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg leads to higher primary: investigator‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review

Oral retinoids: alitretinoin 10 mg vs placebo

Primary: participant‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg leads to higher primary: participant‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review