Findings

What do systematic reviews say?

366 questions · 703 findings · 59 reviews · All outcomes

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No studies found 20 · 2.8%GRADE not reported 630 · 89.6%Very low 27 · 3.8%Low 12 · 1.7%Moderate 7 · 1%High 7 · 1%

0-19 remaining teeth vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the crude HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 2.27 (95% CI 1.50 to 3.43; 1 study, I2 not applicable (single study)); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Crude
HR 2.27 [1.50, 3.43]
1 study · 4380 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Adjusted for age/sex
HR 1.29 [1.08, 1.53]
3 studies · 186749 participants
GRADE not reported
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.98 [1.86, 2.10]
4 studies · 191129 participants
Moderate

Show 1 more finding

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report · Multivariable-adjusted
HR 1.19 [1.13, 1.26]
4 studies · 191129 participants
Moderate

Edentulous (0 remaining teeth) vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 2.65, 95% CI 1.77 to 3.98; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.65 [1.77, 3.98]
2 studies · 130669 participants
High

1-19 remaining teeth vs 20-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 1.69, 95% CI 1.13 to 2.53; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 1.69 [1.13, 2.53]
2 studies · 165066 participants
High

Edentulous (0 remaining teeth) vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 2.27, 95% CI 1.82 to 2.83; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.27 [1.82, 2.83]
8 studies · 180222 participants
High

0-10 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 0-10 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.65, 95% CI 1.84 to 3.81; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival… 2021 All outcomes
Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report
RR 2.65 [1.84, 3.81]
4 studies · 193546 participants
High

Intervention not reported

Development of carious lesions on sealed occlusal pits and fissures

The intervention led to lower development of carious lesions on sealed occlusal pits and fissures; GRADE not reported.

1 finding from 1 review

Caries-Preventive Effect of High-Viscosity Glass Ionomer and Resin-Based Fissure Sealants on Permanent Teeth: A… 2016 All outcomes
60 months
RD -0.07 [-0.14, -0.01]
2 studies
GRADE not reported