Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Adverse events · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults at one time of day (6 am to 7 am) vs another time of day (10 pm to midnight)

Number of participants requiring recatheterisation · adults with short‐term indwelling urethral catheters that need to be removed

Removal of short‐term indwelling urethral catheters in adults at one… may leads to lower number of participants requiring recatheterisation compared with another time of day (10 pm to midnight) (low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults at one time of day (6 am to 7 am) vs another time of day (10 pm to midnight)

Symptomatic catheter associated urinary tract infection · adults with short‐term indwelling urethral catheters that need to be removed

It is very uncertain whether removal of short‐term indwelling urethral catheters in adults at one… changes symptomatic catheter‐associated urinary tract infection (CAUTI) compared with another time of day (10 pm to midnight) (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults at one time of day (6 am to 7 am) vs another time of day (10 pm to midnight)

Dysuria · adults with short‐term indwelling urethral catheters that need to be removed

Removal of short‐term indwelling urethral catheters in adults at one… showed no clear difference in dysuria compared with another time of day (10 pm to midnight) (low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults at one time of day (6 am to 7 am) vs another time of day (10 pm to midnight)

Condition‐specific QoL or generic QoL measure · adults with short‐term indwelling urethral catheters that need to be removed

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Timing of insemination for intrauterine insemination with donor sperm: luteinising hormone (LH) + 1 day vs LH + 2 days

Clinical pregnancy rate · women starting donor sperm treatment

It is very uncertain whether timing of insemination for intrauterine insemination with donor… changes clinical pregnancy rate compared with LH + 2 days (very low certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review