Findings

What do systematic reviews say?

406 questions · 416 findings · 20 reviews · Common Mental Disorders

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No studies found 73 · 17.5%GRADE not reported 9 · 2.2%Very low 144 · 34.6%Low 123 · 29.6%Moderate 59 · 14.2%High 8 · 1.9%

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 723 participants
High
Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 685 participants
High

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Withdrawals due to adverse events · adults with panic disorder

Serotonin‐norepinephrine reuptake inhibitors showed no clear difference in number of dropouts due to adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
RR 1.49 [0.92, 2.4]
4 studies · 1531 participants
Moderate

Selective serotonin reuptake inhibitors vs placebo

Subjective sleep quality or quantity · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 135 participants
Low

Selective serotonin reuptake inhibitors vs placebo

Other subjective measures of sleep (total sleep time, sleep onset latency, nocturnal awakenings and subjective sleep efficiency) (PSQI) (at 12 weeks) · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Selective serotonin reuptake inhibitors vs placebo

Adverse events (at 12 weeks) · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Very low

Selective serotonin reuptake inhibitors vs placebo

PSG sleep outcomes (at 12 weeks) · adults with insomnia

1 finding from 1 review

Antidepressants for insomnia in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Tricyclic antidepressants vs benzodiazepines

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 998 participants
Very low
Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Tricyclic antidepressants vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

TCAs may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 2.1 [1.13, 3.93]
2 studies · 848 participants
Low

Selective serotonin reuptake inhibitors vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

It is very uncertain whether SSRIs changes failure to respond compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.93 [0.48, 1.8]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether SSRIs changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.71 [1.03, 2.84]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

It is very uncertain whether SSRIs changes failure to remit compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.12 [0.79, 1.59]
1 study · 154 participants
Very low

Selective serotonin reuptake inhibitors vs benzodiazepines

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Selective serotonin reuptake inhibitors vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

It is very uncertain whether SSRIs changes number of dropouts due to adverse effects compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.2 [0.55, 2.61]
1 study · 154 participants
Very low

Tricyclic antidepressants vs SSRI

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCAs showed no clear difference in failure to respond compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.08 [0.71, 1.66]
4 studies · 438 participants
Low

Tricyclic antidepressants vs SSRI

Leaving the study early · adults with panic disorder

TCAs showed no clear difference in total number of dropouts compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.98 [0.65, 1.48]
7 studies · 928 participants
Low

Tricyclic antidepressants vs SSRI

Failure to remit at endpoint · adults with panic disorder

TCAs showed no clear difference in failure to remit compared with SSRI (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.89 [0.63, 1.26]
5 studies · 475 participants
Moderate

Tricyclic antidepressants vs SSRI

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 243 participants
Very low

Tricyclic antidepressants vs SSRI

Withdrawals due to adverse events · adults with panic disorder

TCAs showed no clear difference in number of dropouts due to adverse effects compared with SSRI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.43 [0.82, 2.48]
5 studies · 476 participants
Low

Tricyclic antidepressants vs MAOI

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

TCA showed no clear difference in failure to respond compared with MAOI (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.59 [0.28, 1.26]
1 study · 135 participants
Low

Tricyclic antidepressants vs MAOI

Leaving the study early · adults with panic disorder

TCA showed no clear difference in total number of dropouts compared with MAOI (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.84 [0.61, 1.17]
2 studies · 228 participants
Moderate