Findings

What do systematic reviews say?

613 questions · 624 findings · 42 reviews · Headline outcomes only

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No studies found 85 · 13.6%GRADE not reported 37 · 5.9%Very low 211 · 33.8%Low 181 · 29%Moderate 92 · 14.7%High 18 · 2.9%

Selective serotonin reuptake inhibitors vs cognitive behavioural therapy

Adverse effects ‐ adverse event profile · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs doxepin

Cognitive function · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs doxepin

Quality of life · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Paroxetine vs doxepin

Adverse effects · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 67 participants
Moderate

Amitriptyline vs nomifensine

> 50% reduction in depressive symptoms · people with epilepsy and depression

Amitriptyline showed no clear difference in > 50% reduction in depressive symptoms compared with nomifensine (low certainty).

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
RR 0.55 [0.28, 1.06]
1 study · 28 participants
Low

Amitriptyline vs nomifensine

Mean depression scores · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

fluoxetine:desvenlafaxine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

citalopram:paroxetine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

mirtazapine:vortioxetine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

paroxetine:sertraline · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

paroxetine:venlafaxine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vilazodone:paroxetine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vortioxetine:paroxetine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

sertraline:venlafaxine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vilazodone:sertraline · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vortioxetine:sertraline · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vilazodone:venlafaxine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

vortioxetine:venlafaxine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

sertraline:citalopram · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

vilazodone:vortioxetine · children and/or adolescents with depression

1 finding from 1 review

New generation antidepressants for depression in children and adolescents: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low