Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

401 questions · 403 findings · 75 reviews · Headline outcomes only

No studies found 79 · 19.6%GRADE not reported 18 · 4.5%Very low 91 · 22.6%Low 110 · 27.3%Moderate 79 · 19.6%High 26 · 6.5%

Summary of findings: catgut implantation at acupoints plus antiepileptic drugs vs antiepileptic drugs alone

Frequency of adverse effects ‐ anorexia ( · people with epilepsy

Summary of findings: catgut implantation at acupoints plus… showed no clear difference in frequency of adverse effects ‐ anorexia ( compared with antiepileptic drugs alone (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture plus valproate vs valproate

50% or greater reduction in seizure frequency · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in 50% or greater reduction in seizure frequency ( compared with valproate alone (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture plus valproate vs valproate

Frequency of adverse effects ‐ dizziness ( · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ dizziness ( compared with valproate alone (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture plus valproate vs valproate

Frequency of adverse effects ‐ malaise ( · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ malaise ( compared with valproate alone (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture plus valproate vs valproate

Frequency of adverse effects ‐ sleepiness ( · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ sleepiness ( compared with valproate alone (low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Primary outcome: Histological complete response ( available‐case analysis) No residual LM in staged excision 2 months post‐treatment · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in primary outcome: Histological complete response (intention‐to‐treat)… compared with imiquimod 5% cream alone (low certainty).

2 findings from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Secondary outcome: Inflammatory response (number of lesions with grade 2 or 3) Grade 2 or 3 Inflammation² · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel may leads to higher secondary outcome: Inflammatory response (number of lesions with… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review