What do systematic reviews say?

Intervention not reported

• Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis. 2019 All outcomes

  -
  Proportion with untreated caries NR (significantly higher in JIA)
  2 studies
  GRADE not reported

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Short term (<6 weeks)
  Simplified Green & Vermillion Oral Hygiene Index (plaque), mean 10 days; percent mean difference 65 (intervention) vs 15 (control), P<0.0001 favouring the disclosing-agent toothpaste; 40 participants (SoF states 80,…
  1 study · 40 participants
  Very low

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

A single small study suggested developmental enamel defects were more frequent in children with JIA, but the evidence is insufficient (1 study; ungraded).

• Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis. 2019 All outcomes

  United Kingdom (Ahmed et al. 2004)
  The only study reporting developmental enamel defects [22] found the condition more frequent among children with JIA than healthy peers, but the sample size was too small to draw any reliable conclusion.
  1 study · 110 participants
  GRADE not reported

Intervention not reported

• Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis. 2019 All outcomes

  -
  Calculus index (presence) NR (significantly higher in JIA)
  1 study
  GRADE not reported

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Evidence on dental maturation was divergent across two studies (one found more advanced maturation in JIA, one found no difference); no clear conclusion (ungraded).

• Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and meta-analysis. 2019 All outcomes

  Finland and Germany (Lehtinen 2000; Ley 2009)
  Two studies gave divergent results: Lehtinen et al. [24] documented more advanced dental development in children with JIA, whereas Ley et al. [40] found dental maturity within the norms of healthy peers.
  2 studies
  GRADE not reported

Electric toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

Electric toothbrush (self, carer or carer-assisted brushing) showed no clear difference in gingival inflammation (medium term) compared with manual toothbrush (self, carer or carer-assisted brushing) (moderate certainty).

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Medium term (6 weeks to 12 months)
  MD 0.02 [-0.06, 0.09]
  2 studies · 120 participants
  Moderate

Special manual toothbrush (self, carer or carer-assisted brushing) vs Manual toothbrush

• Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes

  Medium term (6 weeks to 12 months)
  Comparison 1.6 (graded in the Effects of interventions text; not tabulated in the SoF). Bildt 2010, Superbrush vs conventional, 4 months, 18 participants (1 RCT): carer handling of toothbrush MD 0.50 (95% CI -0.35 to…
  1 study · 18 participants
  Very low

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 226 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 147 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 79 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 226 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 147 participants
  Moderate

NSAIDs vs placebo

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 79 participants
  Moderate

NSAIDs vs placebo

Summary of findings: non‐steroidal anti‐inflammatory drugs showed no clear difference in proportion with at least 1 hospital admission compared with placebo (moderate certainty).

• Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  OR 0.61 [0.37, 1.01]
  4 studies · 286 participants
  Moderate

Intervention not reported

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  33 studies · 3389 participants
  Low

Intervention not reported

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  27 studies · 3089 participants
  Low

Intervention not reported

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 152 participants
  Very low

Intervention not reported

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 522 participants
  Low

Intervention not reported

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1052 participants
  Low

Intervention not reported

The intervention may leads to higher number achieving target Hb or increase ≥1 g/dL (low certainty).

• Parenteral versus oral iron therapy for adults and children with chronic kidney disease 2019 · Cochrane Headline outcomes only
  RR 1.71 [1.43, 2.04]
  13 studies · 2206 participants
  Low